系统性红斑狼疮的中医证候与用药文献分析

Literature study of TCM pattern and medicine-use analysis of systemic lupuserythematosus

目的基于中国期刊全文数据库（CNKI）收录的中医药诊治系统性红斑狼疮的文献，探讨系统性红斑狼疮的中医辨证论治规律。方法检索1999年1月-2014年7月CNKI收录的中医药治疗系统性红斑狼疮的文献，对文献中的证型、方药进行标准化整理、频次统计和归类分析。结果通过标准化整理，将系统性红斑狼疮中医证型归纳为14种，主要证型有热毒炽盛23次（15．13％）、气阴两虚21次（13．82％）、气血瘀滞20次（13．16％）。证候病位主要在肝、脾、肾。证候要素包括实性（65．30％）和虚性（34．70％），实性证候要素以火热、血瘀、毒邪、气滞、湿热、痰浊为主，虚性证候要素以阴虚、气虚、阳虚、血虚为主。共得中药201种，总用药频次为1669次，可分为十七大类，前3位依次为清热药、补虚药、活血化瘀药。药物归经以肝经、肺经、胃经、心经、脾经、肾经居多。结论系统性红斑狼疮的发病实性要素主要责之热毒，虚性要素主要责之气阴亏虚，治疗应虚实并重。

Objective To study the rule with the treatment based on the pattern differentiation of systemic lupus erythematosus, by analyzing the literature of traditional Chinese medicine for the treatment of systemic lupus erythematosus from January 1999 to July 2014 included in China National Knowledge Infrastructurc（CNKI） and summarizing the frequency of TCM pattern and medicine. Methods The frequency statistics and classified analysis were used to describe the patterns and medicines. Results There were 14 patterns, the common patterns are pyretic toxicity with 23（15.13%）, deficiency of both qi and yin with 21（13.82%）, qi and blood stasis with 20（13.16%）. The disease was involved with liver, spleen and kidney. Pattern factors were mainly sthenia factors, accounting for 65.30% of the total, including hot, blood stasis, toxin, damp-heat, qi stagnation, phlegm; asthenia factors were accounted for 34.70% of the total, including deficiency of yin, deficiency of qi, deficiency of yang and deficiency of blood. There were 201 medicines included, the total frequency was 1 669, which could be into 17 categories. The top three were heat-clearing, tonic and stasis-dissolving medicines. Medicine tropisms are mainly lung tropism, stomach tropism, liver tropism, heart tropism, spleen tropism and kidney tropism, accounting for 88.12% of the total. Conclusions Pyretic toxicity is responsible for the sthenia factors of systemic lupus erythematosus, and deficiency of qi and yin is the main responsibility for asthenia factors, treatment should pay attention to both sthenia and asthenia factors.