抗IgD抗体及在自身免疫病中的作用

Anti-IgD antibody and its role in autoimmune diseases

抗免疫球蛋白D抗体(anti-immunoglobulin D antibody,抗IgD抗体)一直以来主要作为工具药来研究正常B细胞上的膜结合型IgD(membrane IgD,m IgD)。最新研究表明,在病理状态下,抗IgD抗体可以通过选择性清除成熟B细胞、降低自身抗体的水平、抑制B细胞上B细胞活化因子(B cell activating factor belonging to the TNF family,BAFF)的过多表达等来影响自身免疫病的进程。通过抗IgD抗体的治疗,能明显缓解类风湿关节炎(rheumatoid arthritis,RA)、系统性红斑狼疮(systemic lupus erythematosus,SLE)等模型小鼠的病变。抗IgD抗体的研究不断深入,将为其作为研究治疗自身免疫病的靶点提供新思路。本文就抗IgD抗体的免疫学功能和在自身免疫病中的相关作用的研究进展做一综述。

Anti-immunoglobulin D antibody（ anti-IgD antibody） has been mainly used as drugs to study membrane IgD（ m IgD） on normal B cells. However,recent studies showed that,the process of autoimmune diseases was changed by selectively depleting mature B cells,reducing the levels of autoantibodies,and inhibiting excessive expression of BAFF with anti-IgD antibody treatment. Anti-IgD antibody can also significantly improve the incidence of animal models as rheumatoid arthritis（ RA） or systemic lupus erythematosus（ SLE）. The deepening of research on anti-IgD antibody may pave the way to develop anti-IgD antibody as a therapeutic target in treating autoimmune diseases in the future. The research progress in immunological function of anti-IgD antibodies and its relevant role in autoimmune diseases were reviewed.