摘要
目的了解浙江省台州市2009--2012年新报告成年HIV感染者中合并感染HCV的情况,分析HIV/HCV合并感染者中血浆HCV病毒载量水平。方法对2009--2012年浙江省台州市新报告的572例成年HIV感染者检测HCV抗体,并对HCV抗体阳性的标本进行HCVRNA定量检测。结果共有42例HCV抗体检测阳性,HIV感染者中HCV合并感染率为7.3%(95%CI:5.2%-9.5%)。46—86岁HIV感染者的HCV合并感染率显著低于18~45岁年龄组(OR=0.12,95%CI:0.02—0.58);高中及以上文化程度的HIV感染者HCV合并感染率显著低于小学及以下文化程度者(OR=0.13,95%CI:0.02-0.78);经血传播HIV感染者HCV合并感染率显著高于异性传播HIV感染者(0R=49.46,95%CI:13.71—178.48);同性传播HIV感染者HCV合并感染率则低于异性传播HIV感染者(OR=0.11,95%CI:0.01~0.86)。42例HIV/HCV合并感染者中33例(78.6%)血浆HCV病毒载量在检测限以上,HCV复制相对活跃,其中HBsAg阳性者血浆HCVRNA检出率(100%)显著高于HBsAg阴性者(75.7%)(P=0.002)。9例(21.4%)血浆HCV病毒载量则低于检测下限(5.0×10^2IU/m1),处于相对抑制状态。单因素logistic回归分析未发现HIV/HCV合并感染者HCV相对抑制率与其社会人口学特征、HIV传播途径、CD4+T淋巴细胞计数等有关联。结论浙江省台州市HIV感染者中HCV感染率较高,多数HIV/HCV合并感染者血浆HCV病毒载量也较高,其对病情进展影响有待持续观察。
Objective To examine the prevalence and correlates of hepatitis C virus (HCV) co-infection as well as plasma HCV viral load among newly diagnosed HIV-infected adults during 2009-2012 in Taizhou prefecture of Zhejiang province, China. Methods Five hundred and seventy-two adults who were newly diagnosed as HIV-infection were screened for anti-HCV immunoglobulin G (IgG). Plasma HCV RNA was quantified if positive for HCV IgG. Results Forty-two (7.3%) out of the 572 HIV-infected adults were tested positive for HCV IgG. HCV infection was more likely to occur among participants who were infected with HIV through blood transmission (OR = 49.46,95% CI: 13.71-178.48 ). Otherwise, HCV infection was less likely to occur among participants who were under 46-86 years of age (OR=0.12, 95%CI: 0.02-0.58), those with mode of homosexual transmission of HIV (OR=0.11,95% CI: 0.01-0.86), with education of high school or above (OR=0.13, 95% CI: 0.02-0.78). Thirty-three (78.6%) of the total 42 HIV-HCVpatients with coinfection had detectable plasma HCV RNA, whereas 9 (21.4% ) had undetectable plasma HCV RNA (i.e., lower than 5.0 × 10^2 IU/ml) or known as relative HCV viral suppression. No significant associations were noticed on factors as: HCV viral suppression and demographics, HIV transmission route and CD4 + T-cell counts according to univariate regression analyses. Conclusion Prevalence of HCV co-infection was relatively high among newly diagnosed HIV-infected adults in this study area. Majority of the HIV-HCV coinfected patients had detectable plasma HCV RNA, of which the long term impact on disease progression deserves called for further research.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2015年第8期862-866,共5页
Chinese Journal of Epidemiology
基金
国家自然科学基金(81373062)