肺部感染患者外周血TNFa、SP、VIP水平的变化

Variations of TNFa ,SP ,VIP in peripheral blood in patients with pulmonary inflamation

目的 :探讨肺部感染患者肿瘤坏死因子(TNFa)、P物质 (SP)、血管活性肠肽 (VIP)水平的变化。方法 :用放射免疫方法测定肺心病急性加重期和肺炎患者及对照组外周血TNFa、SP、VIP的水平。结果 :肺心病急性加重期和肺炎患者外周血TNFa水平升高 ,SP水平降低 ,而VIP水平无明显变化。肺心病急性加重组SP、TNFa水平与肺炎组无明显差异。结论 :TNFa。

Objective: To probe into the role of TNFa ,SP ,and VIP in the pathogenesis of pulmonary inflammation. Methods: Three groups of subjects were studied: patients with chronic pulmonary heart disease in acute stage, patients with pneumonia and normal controls . Their levels of TNFa,SP,and VIP in peripheral blood were measured with radioimmunoassay. Results: The levels of TNFa and SP in patients weresignificantly higher than in the controls, the levels of VIP had no difference among the three groups ,and the levels of TNFa and SP showed no difference between the chronic pulmonary heart disease group in acute stage and pneumonia group. Conclusion: TNFa and SP play important roles in the pathogenesis of pulmonary inflammation.