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Genomic medicine in gastroenterology:A new approach or a new specialty? 被引量:2

Genomic medicine in gastroenterology:A new approach or a new specialty?
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摘要 Throughout history, many medical milestones have been achieved to prevent and treat human diseases.Man's early conception of illness was naturally holistic or integrative. However, scientific knowledge was atomized into quantitative and qualitative research. In the field of medicine, the main trade-off was the creation of many medical specialties that commonly treat patients in advanced stages of disease. However, now that we are immersed in the post-genomic era, how should we reevaluate medicine? Genomic medicine has evoked a medical paradigm shift based on the plausibility to predict the genetic susceptibility to disease. Additionally, the development of chronic diseases should be viewed as a continuum of interactions between the individual's genetic make-up and environmental factors such as diet, physical activity, and emotions. Thus, personalized medicine is aimed at preventing or reversing clinical symptoms, and providing a better quality of life by integrating the genetic, environmental and cultural factors of diseases. Whether using genomic medicine in the field of gastroenterology is a new approach or a new medical specialty remains an open question. To address this issue, it will require the mutual work of educational and governmental authorities with public health professionals, with the goal of translating genomic medicine into better health policies. Throughout history, many medical milestones have been achieved to prevent and treat human diseases.Man's early conception of illness was naturally holistic or integrative. However, scientific knowledge was atomized into quantitative and qualitative research. In the field of medicine, the main trade-off was the creation of many medical specialties that commonly treat patients in advanced stages of disease. However, now that we are immersed in the post-genomic era, how should we reevaluate medicine? Genomic medicine has evoked a medical paradigm shift based on the plausibility to predict the genetic susceptibility to disease. Additionally, the development of chronic diseases should be viewed as a continuum of interactions between the individual's genetic make-up and environmental factors such as diet, physical activity, and emotions. Thus, personalized medicine is aimed at preventing or reversing clinical symptoms, and providing a better quality of life by integrating the genetic, environmental and cultural factors of diseases. Whether using genomic medicine in the field of gastroenterology is a new approach or a new medical specialty remains an open question. To address this issue, it will require the mutual work of educational and governmental authorities with public health professionals, with the goal of translating genomic medicine into better health policies.
出处 《World Journal of Gastroenterology》 SCIE CAS 2015年第27期8227-8237,共11页 世界胃肠病学杂志(英文版)
关键词 Chronic DISEASES NUTRITIONAL GENOMICS Obesity Liver disease GASTROINTESTINAL DISEASES Chronic diseases Nutritional genomics Obesity Liver disease Gastrointestinal diseases
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  • 1Anna Iacono,Giuseppina Mattace Raso,Roberto Berni Canani,Antonio Calignano,Rosaria Meli.Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms[J].The Journal of Nutritional Biochemistry.2011(8)
  • 2Silvia Sookoian,Carlos J. Pirola.The Genetic Epidemiology of Nonalcoholic Fatty Liver Disease[J].Clinics in Liver Disease.2012(3)
  • 3Ana C. TUYAMA,Charissa Y. CHANG.Non‐alcoholic fatty liver disease[J].Journal of Diabetes.2012(3)
  • 4Xin Gao,Jian‐Gao Fan.Diagnosis and management of non‐alcoholic fatty liver disease and related metabolic disorders: Consensus statement from the S tudy G roup of L iver and M etabolism, C hinese S ociety of E ndocrinology (非酒精性脂肪性肝病与相关代谢紊乱诊疗共识——中华医学会内分泌学分会肝病与代谢学组)[J].Journal of Diabetes.2013(4)
  • 5Günther Silbernagel,Marketa Kovarova,Alexander Cegan,Jürgen Machann,Fritz Schick,Rainer Lehmann,Hans-Ulrich H?ring,Norbert Stefan,Erwin Schleicher,Andreas Fritsche,Andreas Peter.High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet[J].The Journal of Clinical Endocrinology & Metabolism.2012(12)
  • 6Pratt DS,Kaplan MM.Evaluation of abnormal liver-enzyme results in asymptomatic patients[].The New England Journal of Medicine.2000
  • 7María C. Salgado,Isidoro Metón,Ida G. Anemaet,Isabel V. Baanante.Activating transcription factor 4 mediates up-regulation of alanine aminotransferase 2 gene expression under metabolic stress[J]. BBA - Gene Regulatory Mechanisms . 2014 (4)
  • 8Ingalill Rafter,Truls Gr?berg,Anna Kotronen,Lovisa Str?mmer,C. Mattson,Ray Kim,Ewa Ehrenborg,H?kan Andersson,Hannele Yki-J?rvinen,Ina Schuppe-Koistinen,Bj?rn Ekblom,Ian Cotgreave,Bj?rn Glinghammar.Isoform-specific alanine aminotransferase measurement can distinguishhepatic from extrahepatic injury in humans[J]. International Journal of Molecular Medicine . 2012 (5)
  • 9Christopher Coss,Matt Bauler,Ramesh Narayanan,Duane Miller,James Dalton.Alanine Aminotransferase Regulation by Androgens in Non-hepatic Tissues[J]. Pharmaceutical Research . 2012 (4)
  • 10Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease[J]. Atherosclerosis . 2011 (2)

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