炔雌醇环丙孕酮联合二甲双胍治疗肥胖型多囊卵巢综合征的疗效分析

Efficacy of ethinylestradiol and cyproterone combined with metqormin in the treatment of patients with obesity and polycystic ovary syndrome

目的分析炔雌醇环丙孕酮与二甲双胍联合治疗肥胖型多囊卵巢综合征患者的临床效果。方法选取中山市博爱医院妇科2013年3月至2014年3月收治的80例肥胖型多囊卵巢综合征患者,按随机抽样法分为对照组和观察组,各40例。对照组单纯给予炔雌醇环丙孕酮片进行治疗,观察组采用炔雌醇环丙孕酮片联合二甲双胍治疗。结果治疗前两组BIM、FIN、IR、T、FSH、LH、E2均无差异(P>0.05);治疗后观察组除BIM外,FIN、IR、T、FSH、LH、E2均低于对照组(P<0.05)。结论炔雌醇环丙孕酮片联合二甲双胍对肥胖型多囊卵巢综合征效果显著,可有效调节卵巢激素的分泌,值得临床应用及推广。

Objective To study the efficacy of ethinylestradiol and cyproterone combined with metqormin in the treatment of pa-tients with obesity and polycystic ovary syndrome.Methods 80 patients with obesity and polycystic ovary syndrome treated from March of 2013 to March of 2014 in Zhongshan Boai Hospital were selected and randomly divided into two groups,40 cases in each group.The control group was treated with ethinylestradiol and cyproterone and observation group was treated with ethinylestradiol and cyproterone combined with metqormin.Results Before treatment,BIM,FIN,IR,T,FSH,LH and E2 of two groups were not different （P 〉0.05）.After treatment,FIN,IR,T,FSH,LH and E2 of observation group were lower than those of control group （P 〈0.05）.Con-clusion For patients with obesity and polycystic ovary syndrome,ethinylestradiol and cyproterone combined with metqormin has an ob-vious efficacy and could efficiently adjust the secretion of ovarian hormone.It is worthy of clinical application and promotion.