不同化疗途径治疗进展期胃癌患者的临床疗效观察

Efficacy of chemotherapy through different routes in the treatment of patients with advanced gastric cancer

目的观察不同化疗途径治疗进展期胃癌患者的临床疗效。方法选取2012年12月至2014年6月洛阳市第三人民医院收治的64例进展期胃癌患者,随机分为甲乙两组,各32例。甲组给予选择性动脉灌注化疗,乙组给予全身静脉化疗,均完成2个周期化疗,比较两组治疗后的临床疗效、不良反应、生活质量。结果治疗后甲组的临床有效率为78.13%,明显高于乙组(62.50%),甲组在不良反应、生活质量方面亦明显优于乙组(P<0.05)。结论选择性动脉灌注化疗治疗进展期胃癌临床疗效好,不良反应少,且操作简单、安全,易于被患者接受,值得临床推广。

Objective To observe the efficacy of chemotherapy through different routes in the treatment of patients with ad-vanced gastric cancer.Methods 64 patients with advanced gastric cancer in the Third People’s Hospital of Luoyang from De-cember of 201 2 to June of 201 4 were choosed and divided into group A and B,32 cases in each group.Group A were given se-lective arterial infusion chemotherapy,and group B were given systemic intravenous chemotherapy.2 cycles of chemotherapy were completed.The clinical efficacy,adverse reaction,quality of life of two groups after treatment were compared.Results After treatment,the clinical effective rate was 78.1 3% in group A,obviously higher than that in group B （62.50%）.The adverse reac-tions,quality of life in Group A were both superior than group B,the differences were statistically significant （P 〈0.05）.Conclu-sion The clinical efficacy of selective arterial infusion chemotherapy in treatment of adversed gastric cancer was good with less ad-verse reactions,and the operation was simple,safe,easy to be accepted by patients.It deserves the clinical expansion.