抑郁症急性发作期和缓解期多导睡眠图特征

Characteristics of Polysomnography during Acute Attack and Remission in Depression

目的:探讨抑郁症患者急性发作期和缓解期多导睡眠图(PSG)特征,以及PSG指标与临床症状的相关性。方法:采用PSG和匹兹堡睡眠质量指数量表(PSQIS)对抑郁症组(54例)和23例健康者进行评估;汉密尔顿抑郁量表(HAMD)和焦虑量表(HAMA)评定抑郁症组。结果:与对照组比,抑郁症组治疗前入睡潜伏期延长,总睡眠时间减少,睡眠效率下降,快眼动潜伏期缩短,N1、2期睡眠增多,N3期、快眼动期睡眠减少(P<0.01);治疗后,抑郁症组快眼动潜伏期缩短、N3期睡眠减少(P<0.01);抑郁症组治疗前、后PSQIS评估与PSG监测比差异均有统计学意义(P<0.01);Pearson相关分析示,快眼动潜伏期、N3期睡眠与HAMA、HAMD无统计学意义。结论:快眼动潜伏期缩短、慢波睡眠减少可能是反映抑郁症疾病特征性的电生理指标。

Objective：To explore the characteristics of polysomnogram（PSG）during acute attack and remission in depression and the correlations between PSG indexes with clinical symptoms. Methods：PSG and Pittsburgh sleep quality index scale（PSQIS）were used to evaluate 54 depression patients and 23 healthy person. Hamilton rating scale for depression（HAMD）and Hamilton rating scale for anxiety（HAMA）were used to evaluate the patients＇ clinical symptoms. Results：Compared with control group, the prolonged sleep latency,shortened total sleep time,decreased sleep efficiency,increased awake time,shortened rapid eye movement sleep latency,and increased N1,2 stage,decreased N3 and rapid eye movement stage sleep time in the depression group were significantly determined before treatment（P0.01）. The shortened rapid eye movement sleep latency and shortened N3 stage sleep in the depression group were determined after treatment（P0.01）. The depression group also had subjective sleep disturbance with that of objective sleep（P0.01）. There had no statistical significance in rapid eye movement sleep latency and N3 stage sleep with HAMA,HAMD by Pearson analysis. Conclusion ： The shortened rapid eye movement sleep latency and low wave sleep deficit may be the electrophysiological parameters which reflect the trait marker in depression.