盐酸洛美沙星乳膏剂的制备与含量测定

Preparation and determination of Lomefloxacin Hydrochloride Cream

目的制备盐酸洛美沙星乳膏剂并建立含量测定方法。方法盐酸洛美沙星为主药,采用高效液相色谱法测定制剂中盐酸洛美沙星的含量。结果盐酸洛美沙星在12~28μg·m L-1范围内呈良好的线性关系,A=-1.747 6×104＋6.534 4×104C（r=0.999 8）,平均回收率99.74%;RSD为0.39%。结论该乳膏剂处方合理,制备工艺简单,含量测定方法操作简单,结果准确。

Objective To prepare Lomefloxacin Hydrochloride Cream and establish the determination method. Methods Lomefloxacin hydrochloride as main medicine,its content was determinated by HPLC. Results The lomefloxacin hydrochloride showed a good linear relationship in 12 ~ 28 μg·m L- 1,A =- 1. 747 6 × 104＋ 6. 534 4 × 104C（ r =0. 999 8）,the average recovery was 99. 74% with RSD of 0. 39%. Conclusion The prescription was reasonable and preparation technological was easy. The method of determination was simple and accurate.