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血清CA72-4与胃蛋白酶原检测在胃癌诊断中的应用 被引量:1

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摘要 目的探讨肿瘤标志物CA72-4联合胃蛋白酶原(PG)Ⅰ、PGⅡ检测在胃癌诊断中的使用价值。方法用电化学发光法检测137例非萎缩性胃炎组,98例萎缩性胃炎组,91例胃癌组患者血清CA72-4表达水平,用酶联免疫吸附法(ELISA)检测血清PGⅠ、PGⅡ表达水平,并计算PGR(PGⅠ/PGⅡ)。结果胃癌组血清CA72-4表达水平高于其他组(<0.05),萎缩性胃炎组和胃癌组血清PGⅠ及PGR均低于非萎缩性胃炎组(均<0.05),3组PGⅡ表达水平差异无统计学意义(>0.05)。血清CA72-4=16.23 k U/L时诊断胃癌的敏感度为87.8%,特异度为92.0%,曲线下面积为0.843±0.056;血清PGR=3.01时诊断胃癌的敏感度为74.2%,特异度为78.4%,曲线下面积为0.816±0.042。用CA72-4诊断胃癌,阳性率为75.8%;用PGR诊断胃癌,阳性率为62.6%;联合两者检测,诊断胃癌的阳性率为91.2%。结论血清CA72-4表达水平升高和PGR值下降与胃癌的发生密切相关,联合检测有助于提高胃癌诊断的阳性率检出率,对胃癌的诊断具有重要的临床意义。
出处 《现代实用医学》 2015年第7期894-896,F0003,共4页 Modern Practical Medicine
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参考文献6

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