Kruppel样因子1在珠蛋白基因表达调控中的作用

Roles of Kriippel-like factor 1 in regulation and expression of hemoglobin gene

Krtippel样因子（KLF）1属于锌指蛋白家族，是红细胞系特异性转录因子。KLF1在红细胞生成中发挥多种作用，如可通过调节染色质构象，活化β珠蛋白基因转录；可根据不同作用背景、协同因子及KLFl蛋白修饰状态，对γ珠蛋白基因表达起着活化或抑制的调控作用。目前，KLF1对珠蛋白基因表达的确切调控机制迄今仍未阐明，尚需进一步研究探讨。笔者拟就KLF1在珠蛋白基因表达调控中的作用进行综述，旨在初步探讨KLF1作为β地中海贫血基因治疗靶向因子的可能性。

Kruppel-like factor （KLF） 1 is a transcription factor belonging to the KLF family and it is specific transcription factor of erythrocyte series. KLF1 plays important roles in erythropoiesis, such as activating the transcription of β-hemoglobin through the role of modification of chromatin structure. As to γ-hemoglobin, KLF1 may have two opposite effects on the regulation of y-hemoglobin expression according to different contexts, cofactors and modified status. The exact roles of KLF1 in regulation of hemoglobin haven＇t been elucidated so far, which need to be further explored. This paper will review the roles of KLF1 in regulation of hemoglobin, in order to discuss the possibility of KLF1 working as a molecular target for therapy of the β thalassanemia.