泛素连接酶组成型光形态建成蛋白1的生物学特性及其在肿瘤中所起作用的研究进展

Research progress of biological characteristics of ubiquitin ligase constitutive photomorphogenesis protein 1 and its roles in tumors

组成型光形态建成蛋白（COP）1是调节植物在光照条件下生长和发育的重要分子。近年研究发现，COP1可表达于哺乳动物细胞中，参与调节DNA损伤修复、糖代谢、脂肪代谢及细胞自噬等生物学行为。此外，COP1在实体肿瘤与血液肿瘤中的异常表达与肿瘤进展及患者预后和存活密切相关。COP1作为E3泛素连接酶家族成员之一，可直接招募下游靶分子，如P53、c-Jun、CCAAT增强子结合蛋白（C／EBP）α及ETV等，介导下游靶分子泛素化降解，进而参与肿瘤的发生、发展。笔者拟就COP1的生物学特性及其在肿瘤中的研究进展进行综述。

The constitutive photomorphogenic protein （COP）1 is an important molecule to regulate the growth and development of plants under the lighting condition. In recent years, COP] has been found in mammalian cells, which involves in the regulation of DNA damage, glucose metabolism, lipid metabolism, autophagy and so on. In addition, the abnormal expression of COP1 in solid tumor and blood tumor is closely related to tumor progression, prognosis and patients＇ survival. COP1, as one of the E3 ubiquitin ligase family members, can directly recruit downstream target molecules, such as P53, c-Jun, CCAAT- enhancer-binding protein （C/EBP）α, ETV and mediate the ubiquitin degradation, then participate in the occurrence and development of tumor. In this article, the authors intend to review the research progress of COP1 in its structure, function, regulation and biological behavior of participation in cancer.