期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

丹皮酚对人舌癌Tca8113细胞增殖的影响 被引量：1

Effect of Paeonol on Proliferation of Human Tongue Carcinoma in Tca8113 Cell
下载PDF
导出
摘要 目的探讨丹皮酚(paeonol)对人舌癌TCA8113细胞生物学行为的影响。方法用MTT法检测不同浓度的丹皮酚对TCA8113细胞增殖的抑制的作用;用ELISA实验检测细胞血管内皮生长因子(VEGF)蛋白的表达水平。结果 MTT实验表明丹皮酚对TCA8113细胞的增殖有抑制作用,并随浓度增加抑制作用增强;ELISA实验提示丹皮酚抑制TCA8113细胞分泌VEGF蛋白。结论丹皮酚可以抑制TCA8113细胞增殖,抑制VEGF蛋白的分泌。 Objective It is to research the effect of paeonol on the biological behavior of human tongue carcinoma in TCA8113 cells. Methods MTT was used to detect the inhibition of paeonol on the proliferation of TCA8113 cells, with different concentration. Expression level of VEGF was detected by ELISA assay. Results MTT results showed that paeonol has inhibition effects on the proliferation of TCA8113 cell. The inhibition effects are enhanced with the increase of its concentration. ELISA assay indicates that paeonol has inhibited TCA8113 cells secrete VEGF. Conclusion The proliferation of TCA8113 ceils can be inhibited by paeonol, and paeonol can inhibi TCA8113 cells secrete VEGF.
作者 刘柏林
机构地区 江苏护理职业学院检验药学系
出处 《中国继续医学教育》 2015年第20期200-201,共2页 China Continuing Medical Education
关键词 舌癌 TCA8113 丹皮酚 Tongue carcinoma, TCA8113, Paeonol
分类号 R285 [医药卫生—中药学]
  • 相关文献

参考文献5

  • 1Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer[J]. OralOncol., 2009, 45 (4-5): 30q-316.
  • 2Horng CT, Shieh PC, Tan TW, et al. Paeonol suppresses chondrosarcoma metastasis through up-regulation of miR-141 by modulating PKC 8 and c-Src signaling pathway[j]. Int J Mol Sci., 21}14, 15 (7): 11760-11772.
  • 3Lee HJ, Kim SA, Je~mg SJ, et al. Paeonol Oxime Inhibits bFGF- Induced Angiogenesis and Reduces VEGF Levels in Fibmsarcoma Cells[J]. PLoS One, 2010, 5 ( 8 ) : e12358.
  • 4Yin J, Wu N, Zeng F, et al. Paeonol induces apoptosis in human ovarian cancer cells[J]. Acta Histochem, 21113, 115 ( 8 ) : 835-839.
  • 5王阿曼,蔡欣,周涛,刘基巍.MMP-2、VEGF、CD105和Ki-67在小细胞肺癌中的表达及预后相关性研究[J].临床肿瘤学杂志,2012,17(11):988-993. 被引量：16

二级参考文献11

  • 1Frank B, Michael V, Sylvia C, et al. Ras P21 express ion in the progression of breast cancer [ J]. Hum Pathol, 1987, 21 (5) : 1268 - 1275.
  • 2Banvois B. New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: outside-in signaling and rela- tionship to tumor progression[ J]. Biochim Biophys Acta, 2012, 1825 ( 1 ) :29 - 36.
  • 3Daniele A, Zito AF, Giannelli G, et al. Expression of metallo- proteinases MMP-2 and MMPo9 in sentinel lymph node and serum of patients with metastatic and non-metastatic breast cancer [ J ]. Anticancer Res, 2010, 30(9) :3521 -3527.
  • 4Thomas P, Khokha R, Shepherd FA, et al. Differential expres- sion of MMPs and their inhibitors in non small cell lung cancer [J]. J Pathol,2000, 190(2) :150 - 156.
  • 5Zhan P, Wang J, Lv X J, et al. Prognostic value of vascular en- dothelial growth factor expression in patients with lung cancer [J]. J Thorac Oncol, 2009, 4(9) :1094 - 1103.
  • 6Davidson B, Stavnes HT, Forsund M, et al. CD105 (Endoglin) expression in breast carcinoma effusions is a marker of poor sur- vival[J]. Breast,2010,19(6) :493 -495.
  • 7Takase Y, Kai K, Masuda M,et al. Endoglin (CD105) expres- sion and angio-genesis status in small cell lung cancer [ J ]. Pathol Res Pract, 2010, 206( 11 ) : 725 -730.
  • 8Minhajat R, Moil D, Yamasaki F, et al. Organ-specific endoglin (CD105) expression in the angiogenesis of human cancers [ J ]. Pathol Int, 2006, 56(12) :717 -723.
  • 9Tokyol C, Aktepe F, Dilek FH, et al. Expression of cyclooxyge- nase-2 and matrix metalloproteinase-2 in adenomyosis and endom- etrial polyps and its correlation with angiogenesis[J]. Int J Gyne- col Pathol, 2009, 28(2) : 148 - 156.
  • 10Chetty C, Lakka SS, Bhoopathi P, et al. MMP-2 alters VEGF expression via aVI33 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells[J]. Int J Cancer, 2010, 127 (5) : 1081-1095.

共引文献15

同被引文献19

引证文献1

二级引证文献7

中国继续医学教育
2015年 第20期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部