肺炎衣原体感染与肺癌血清学研究meta分析

Association of Cpn infection with lung cancer: a meta-analysis of serological studies

目的 综合评价肺炎衣原体（Chlamydia pneumoniae,Cpn）感染与肺癌之间的关系,为肺癌病因研究和临床诊治提供科学依据。方法 检索Medline数据库、中国生物医学文献数据库、中国知识资源总库、维普资讯网、万方数据知识服务平台等多个中英文数据库,收集Cpn感染与肺癌的病例对照研究文献,同时利用所查文献及相关综述的参考文献、Google学术搜索进行滚动搜索补遗,应用Stata 12.0软件进行meta分析。结果 共纳入12篇文献,包括9篇英文文献和3篇中文文献,累计2 557例病例人群和2 756名对照人群;meta分析结果显示,Cpn Ig A抗体阳性和Cpn Ig G抗体阳性与肺癌的合并OR值分别为2.025（95%CI=1.376～2.982）和1.774（95%CI=1.251～2.516）,吸烟者Cpn Ig A和Cpn Ig G阳性与肺癌的合并OR值分别为2.372（95%CI=1.463～3.847）和1.908（95%CI=1.112～3.275）,Cpn Ig A≥16、Cpn Ig A≥64和Cpn Ig G≥16与肺癌的合并OR值分别为1.180（95%CI=1.029～1.353）、1.836（95%CI=1.098～3.068）和1.608（95%CI=1.022～2.531）。结论 Cpn感染与肺癌发生有关,Cpn感染可增加吸烟者患肺癌的风险。

Objective To systematically evaluate the relationship of Chlamydia pneumoniae （Cpn） infection with lung cancer and to provide a scientific basis for etiology research and clinical diagnosis and treatment of lung cancer . Methods Medline, Sinomed, China National Knowledge Infrastructure, VIPdisc, WanFang Data and other databases were searched for the case-control studies on the association of Cpn infection with lung cancer. Meanwhile, Google Schol- ar was used to handsearch for addendum to the databases based on the references of the articles retrieved. Stata 12. 0 soft- ware was applied in meta-analysis. Results Totally 12 eligible studies（9 English articles and 3 Chinese articles） were included, involving 2 557 lung cancer cases and 2 756 controls. The pooled odds ratios （ORs） for Cpn antibody IgA-posi- five and IgG-positive were 2. 025 （95% confidence interval [ 95% CI] ： 1. 376 - 2. 982） and 1. 774 （ 95% CI： 1. 251 - 2. 516 ）. The pooled ORs for Cpn antibody IgA-positive and IgG-positive were 2. 372 （ 95 % CI： 1. 463 - 3. 847 ） and 1. 908 （95% CI： 1. 112 -3. 275 ）among smokers. Cpn infection was identified as a risk factor for lung cancer for the subjects with Cpn antibody IgA of ≥ 16 cutoff value（ OR = 1. 180,95% CI： 1.029 - 1. 353 ）, IgA of ≥64 （ OR = 1. 836 ;95% CI： 1.098 -3.068）,and IgG of ≥16（0R=1.608,95%CI：1.022 -2. 531） Conclusion Cpn infection is associated with lung cancer, particularly among smokers.