氯硝西泮与地西泮治疗颅脑损伤后精神障碍的疗效对比

Efficacy comparison between clonazepam and diazepam in the treatment of psychotic disorder after craniocerebral injury

目的探讨氯硝西泮对颅脑损伤后精神障碍的治疗效果,为临床治疗探索更有效的治疗方式。方法选取昌黎县人民医院2009年3月—2014年3月收治的因各种外伤所致颅脑损伤后发生精神障碍的患者67例,随机分为两组,一组采用氯硝西泮治疗,另一组采用地西泮治疗,比较两组患者用药后入睡时间,贝克-拉汉森狂燥量表(BRMS)评分以及两种药物的疗效。结果两组患者比较,>20 min入睡的患者数氯硝西泮组为1例,地西泮组为7例,2组的差异有统计学意义(P<0.05)。患者治疗前后BRMS评分氯硝西泮组分别为8.7±4.7和2.1±1.8,地西泮组分别为8.9±4.3和4.3±2.2,治疗后2组的差异有统计学意义(P<0.05)。氯硝西泮与地西泮组的总有效率分别为91.4%和78.1%,但二者的差异无统计学意义(P<0.05)。结论在对颅脑损伤后精神障碍的治疗中,氯硝西泮组相比地西泮疗效更加显著,能缩短患者入睡时间,有效改善患者病情,减轻患者症状。

[Objective]To study the efficacy of clonazepam in the treatment of psychotic disorder after craniocerebral injury,explore more effective treatment. [Methods]67 patients with psychotic disorder after craniocerebral injury,who were treated in Changli People’s Hospital from March 2009 to March 2014, were randomly divided into two groups, one group was treated with clonazepam,and other one was given diazepam. The time for falling asleep after medication,scores of Bech-Rafaelsen Mania Scale（BRMS）of two groups were compared,and the efficacy of clonazepam and diazepam were evaluated.[Results]While 1patient in clonazepam group and 7 patients in diazepam group fell asleep in more than 20 minutes,and the differences were statistically significant（P〈0.05）. The BRMS scores in clonazepam group before and after treatment were 8.7±4.7 and 2.1 ±1.8 respectively,while BRMS scores in diazepam group before and after treatment were 8.9 ±4.3 and 4.3 ±2.2 respectively, and there was statistically significant difference in BRMS scores after treatment between two groups（P 〈0.05）. The total effective rate in clonazepam group and diazepam group was 91.4% and 78.1% respectively,but the difference was not statistically significant（P〉0.05）.[Conclusion]Clonazepam has more significant curative effect than diazepam in the treatment of psychotic disorder after craniocerebral injury,and it can shorten the time for falling asleep and effectively alleviate the symptoms in patients.