摘要
[目的]探讨Gal-3蛋白在结直肠癌中的表达及临床意义。[方法]采用免疫组织化学SP法检测Gal-3蛋白在60例结直肠癌组织的表达;另取癌旁正常黏膜20例及结直肠腺瘤20例作为对照组。[结果 ]结直肠癌中Gal-3蛋白的表达明显高于癌旁正常黏膜和结直肠腺瘤(55.0%,10.0%和25.0%,P<0.05)。Gal-3蛋白在侵及浆膜外、TNMⅢ+Ⅳ期、有淋巴结转移组中的表达明显高于未侵及浆膜外(P<0.05)、TNMⅠ+Ⅱ期(P<0.01)、无淋巴结转移组(P<0.05);与年龄、性别、肿瘤大小和分化程度无关。Gal-3蛋白阳性表达患者5年生存率明显低于阴性表达者(P<0.05)。[结论]Gal-3蛋白在结直肠癌中高表达,其可能在结直肠癌的发生发展和浸润转移中起作用,并提示预后不良。
[Purpose] To investigate the expression of Gal-3 protein in colorectal cancer and its clinical significance. [Methods]The expression of Gal-3 protein in 60 cases with colorectal cancer was detected by immunohistochemistry（SP method）,and 20 normal adjacent mucosa and 20 colorectal adnoma as control group were served. [Results] The positive rate of Gal-3 protein in colorectal cancer was significantly higher than that in normal adjacent mucosa and colorectal adnoma（55.0%,10.0% and 25.0%,P〈0.05）. the Gal-3 protein expression level in outside the serosa invasion,lymph node metastasis and TNM stages III ＋IV group was significantly higher than that in within the serosa（P〈0.05）,lymph node metastasis-free group（P〈0.05） and TNM stage I＋II group（P〈0.01）.And Gal-3 protein expression was not related to age,gender,tumor size and differentiation（P〉0.05）.The 5-year survival rate of the patients with positive expression of Gal-3 protein was significant lower than that with negative expression of Gal-3 protein（P〈0.05）.[Conclusion] Gal-3 protein is overexpressed in colorectal cancer,it might play an important role in the carcinogenesis and development of colorectal cancer,and indicates poor prognosis.
出处
《中国肿瘤》
CAS
2015年第8期715-718,共4页
China Cancer
基金
河南省医学科技攻关计划项目(201204157)
