血清尿酸与男性非酒精性脂肪肝的相关性研究

Relationship between serum uric acid and non-alcoholic fatty liver disease in male adults

[目的]探讨血清尿酸和男性非酒精性脂肪肝的相关性。[方法]回顾性分析2010~2014年在本院就诊的82例男性非酒精性脂肪肝患者的临床资料,所有患者经肝脏穿刺病理诊断为NAFLD,根据NAS积分将患者分为SS组、临界NASH组和NASH组,通过单因素分析和Logistic多元回归分析了解各指标在不同组间的差异及相关性;同时根据是否出现肝纤维化将NASH患者分组,通过单因素分析和Logistic多元回归分析了解各指标在不同组间的差异及相关性。[结果]在单因素分析中WC、ALT、AST、GGT、SUA、INS以及HOMA-IR和在不同病理类型的NAFLD患者中差异有统计学意义（P〈0.05）,logistic回归分析提示SUA以及HOMA-IR和NAFLD肝细胞脂肪变性程度呈正相关性（P〈0.05）;同时AST,ALT,GGT和SUA水平在肝纤维化的NASH患者中明显高于无肝纤维化的NASH患者（P〈0.05）,Logistic回归分析证明SUA和NAFLD患者肝纤维化程度呈正相关性（P〈0.05）。[结论]SUA水平升高和NAFLD病理级别进展关系密切,同时SUA是NAFLD肝纤维化的独立危险因素。

[Objective]To explore the relationship between serum uric acid（SUA）and non-alcoholic fatty liver disease in male adults.[Methods]A retrospective study was carried out in our hospital from 2010to2014.Totally 82 male patients with non-alcoholic fatty liver disease were enrolled in this study and all clinical data were collected and analyzed.All patients were divided into three groups including SS,bordline NASH and NASH depending on NAS scores.Furthermore,29 NASH patients were divided into two groups based on fibrosis stage.Univariate analysis and Logistic analysis were used to evaluate differences and correlation of index between the groups.[Results]WC,ALT,AST,GGT,SUA,INS and HOMA-IR were significantly different in each group of NAFLD patients（P〈0.05）,SUA and HOMA-IR were increased with fatty degeneration of hepatocytes in NAFLD patients（P〈0.05）.Besides,AST,ALT,GGT and SUA were higher in NASH patients with F1-4than that with F0（P〈0.05）,and SUA was positive correlated with fibrosis stage in NAFLD（P〈0.05）.[Conclusion]SUA is positively correlated with deterioration of NAFLD and SUA is an independent risk factor of fibrosis in NAFLD.