自拟理坤汤联合克龄蒙对肾虚型卵巢早衰患者性激素水平的影响

Effect of Self- made Li Kun Decoction Combined with Climen in the Treatment of Premature Ovarian Failure Patients with Kidney Deficiency for Improving Sex Hormones Concentrations

目的:观察和分析自拟理坤汤联合克龄蒙对肾虚型卵巢早衰患者血清促卵泡激素、雌二醇、促黄体生成素的影响,从而探讨自拟理坤汤联合克龄蒙对患者性激素水平的作用。方法:将符合纳入标准的60例肾虚型卵巢早衰患者随机分为观察组与对照组,各30例。对照组患者给予克龄蒙人工周期替代疗法治疗,连续3个疗程;观察组在对照组治疗的基础上,口服自拟理坤汤,连续3个疗程。观察自拟理坤汤联合克龄蒙对肾虚型卵巢早衰患者血清促卵泡激素、雌二醇、促黄体生成素的影响,并与对照组比较。结果:自拟理坤汤联合克龄蒙可明显降低患者血清促卵泡激素、促黄体生成素的水平,升高雌二醇的水平,与治疗前比较,差异具有统计学意义(P<0.05或P<0.01);与对照组比较,差异具有统计学意义(P<0.05)。结论:自拟理坤汤联合克龄蒙具有调节患者性激素水平的作用。

Objective：To observe and analyze the effect of self-made Li Kun decoctioncombined with Climen in the treatment of premature ovarian failure patients with kidney deficiency for improving the concentrations of serum FSH, estrogen and LH, in order to explore the action of this kind of treatment for regulating the level of sex hormones.Methods：60 premature ovarian failure patients with kidney deficiency who met the inclusion criteria were randomly divided into an observation group and a control group,with 30 cases in each group.The patients in control group the were treated by Climen as artificial cycle replacement therapy, with 3 courses continuously, while the patients in the observation group were given self-made Li Kun decoction on the basis of the treatment therapy in the control group with 3 courses continuously.After treatment, the levels of FSH, estrogen and LH were observed to demonstrate the effect of self-made Li Kun decoction combined with Cli-men in the treatment of premature ovarian failure patients with kidney deficiency and the effect was compared with that in the control group.Results： The concentrations of FSH and LH were significantly decreased and the level of estrogen was elevated after patients were treated by self-made Li Kun decoction combined with Climen, and the difference was significant compared with that before treatment （P〈0.05 or P〈0.01）.Mo-reover,the difference was significant compared with that in the control group （ P〈0 .05 ） .Conclusion： The treatment of self-made Li Kun decoction combined with Climen has a good effect on improving sex hormone levels of patients.