人工虫草多糖对阿霉素致肾病综合征大鼠的作用研究

Therapeutic effects of cordyceps polysaccharide on adriamycin induced nephritic syndrome in rats

目的:观察人工虫草多糖对肾病综合征模型大鼠的治疗效果。方法:雄性SD大鼠尾静脉注射阿霉素,建立大鼠肾病综合征模型,分为模型组、激素组、人工虫草多糖大、小剂量组及正常对照组。连续药物灌胃21d后观察各组大鼠一般情况,检测24h尿蛋白水平,取血测定血清白蛋白、总胆固醇、甘油三酯、尿素氮、肌酐。结果:与模型组比较,各药物组24h尿蛋白水平均显著降低,人工虫草多糖大及小剂量组能显著降低血清胆固醇及甘油三酯水平,提高血清白蛋白水平。结论:人工虫草多糖能改善阿霉素肾病大鼠生存质量,减轻尿蛋白丢失,提高白蛋白水平,降低胆固醇及甘油三酯水平,并有一定量效关系。

Objective： To observe the therapeutic effects of cordyceps polysaccharide on rat model of nephrotic syndrome induced by adriamycin. Methods： Rat models of nephritic syndrome were established by tail intravenous of adriamycin; model rats were randomly divided into the following groups： the model group, the glucocorticoid group, the cordyceps polysaccharide group of high dose, the cordyceps polysaccharide group of low dose. Intragastric administration was performed continually for 21 days. 24 h urinary protein of all rats was determined at the 21 st day. Then all animals were sacrificed to measured serum albumin, total cholesterol, triglyceride, blood urea nitrogen and creatinine. Results： Compared with the model group, 24 h urinary protein levels in three treated groups were significantly decreased; the levels of serum total cholesterol and triglycerin in two cordyceps polysaccharide groups were obviously lower than those in the model group; and the levels of serum albumin were significantly more increased than model group. Conclusion： Cordyceps polysaccharide is effective in the treatment of chronic kidney disease in rat induced by adriamycin, decreased the contents of 24-hour urinary protein and serum lipid level, increased serum albumin level, and had dose-effect relationship.