中西医结合治疗类风湿关节炎的文献荟萃分析

A meta-analysis of treating rheumatoid arthritis in the integrative medicine

目的：对中西医结合治疗类风湿关节炎的文献进行荟萃分析,为临床治疗类风湿关节炎提供依据。方法：对2008年1月-2014年1月维普、万方等数据库收录的有关“中西医结合治疗类风湿关节炎”的随机对照试验进行检索,应用Jadad量表对纳入的文献报道进行评价、分析,并通过统计学软件Review Manager 5.0对纳入文献实施荟萃分析。结果：共纳入文献12篇,病例总数为960例,采用中西医结合治疗的500例类风湿关节炎患者为研究组,采用西医治疗的460例类风湿关节炎患者为对照组,荟萃分析显示OR=0.32,95%CI=2.35-4.70,Z=6.49,P〈0.00001。结论：对类风湿关节炎患者实施中西医结合疗法,显著减少了单用西药治疗所引起的副反应情况,使用药的耐受性明显增强,且治疗总有效率显著高于单用西药治疗,值得推广应用。

Objective： To analyze clinical effect of TCM medicine on rheumatoid arthritis. Methods： A randomized controlled trial of retrieval was set by the Jadad scale evaluation and analysis of the reports of the included literature, and through statistical software Review Manager 5.0 of included studies carried out a meta-analysis. Results： Totally 12 literatures, a total of 960 cases, by the integrative medicine in 500 cases of rheumatoid arthritis patients as research group, by western medicine treatment for 460 cases of rheumatoid arthritis patients as control group; the meta-analysis indicates that OR=0.32, 95%CI=2.35-4.70, Z=6.49, P〈0.00001. Conclusion： In patients with rheumatoid arthritis（RA） the implementation of integrative medicine combination therapy, can significantly reduce the side effects, drug tolerance significantly enhance; the total efficiency was significantly higher than that of the single western medicine treatment.