Graves病中医证型与血清25(OH)D_3的相关性研究

Study on the TCM relationship between serum 25(OH)D_3 and graves disease

目的:探讨Graves病(Graces Disease,GD)中医证型与血清25(OH)D3的相关性,分析血清25(OH)D3与甲状腺激素及促甲状腺激素受体抗体(TRAb)的相关性。方法:将60例初诊Graves病患者按中医辨证标准分为心肝火旺证(20例)、痰火内扰证(20例)、阴虚阳亢证(20例),为GD组,另取健康者(20例)为对照组,同时检测四组血清25(OH)D3水平及GD组患者游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、三碘甲状腺原氨酸(TT3)、甲状腺素(TT4)、促甲状腺激素(TSH)、TRAb水平。结果:1GD三组证型两两比较,FT3、FT4、TT3、TT4、TSH、TRAb差异有统计学意义(P<0.05),FT3、FT4、TT3、TT4、TRAb水平阴虚阳亢组最高,痰火内扰组其次,心肝火旺组最低;TSH水平心肝火旺组最高,痰火内扰组其次,阴虚阳亢组最低。2与对照组相比,GD组患者25(OH)D3水平明显降低,差异有统计学意义(P<0.05)。GD三组之间25(OH)D3水平有明显差异,其中阴虚阳亢组25(OH)D3水平最低,痰火内扰组其次,心肝火旺组水平最高。3血清25(OH)D3与TSH呈正相关,与FT3、FT4、TRAb呈负相关,与TT3、TT4无相关性。结论:血清25(OH)D3水平与GD中医证型存在相关性,可作为GD中医辨证分型的客观指标。

Objective：To observe the relationship between Graves disease syndromes and serum 25（OH）D3. Methods： 60 patients were divided into 20 cases of Xigan Huowang syndrome,20 cases of Tanhuo Neirao syndrome, 20 cases of Yinxu Yangkang syndrome.20 healthy people as control group.Test all people＇s 25（OH）D3 and GD group＇s FT3, FT4, TT3, TT4, TSH and TRAb. Results： 1Compared with Xingan Huowwang syndrome,Tanhuo Neirao syndrome, Yinxu Yangkang syndrome（P〈0.05）, FT3, FT4, TT3, TT4, TSH and TRAb difference was statistically significant（P〈0.05）. In the content of FT3, FT4, TT3, TT4 and TRAb,Yinxu Yangkang syndrome was the highest. Tanhuo Neirao syndrome was the middle,and Xingan Huowwang syndrome was the lowset（P〈0.05）. In the content of TSH, Xingan Huowwang syndrome was the highest. Tanhuo Neirao syndrome was the middle, and Yinxu Yangkang syndrome was the lowset（P〈0.05）.225（OH）D3 content was lower with statistical difference in GD group（P〈0.05）. 3 syndrome types in the 25（OH）D3 content, there was a significant difference（P〈0.05）. Xingan Huowwang syndrome was the highest. The Tanhuo Neirao syndrome was the middle,and the Yinxu Yangkang syndrome was the lowset（P〈0.05）. 3GD patients 25（OH）D3 level and TSH had positive correlation,negative correlation with FT3, FT4, TRAb, and TT3, TT4 no correlation. Conclusion： There is a relationship between GD syndromes and serum 25（OH）D3, serum 25（OH）D3 can be used as an index for TCM differentiation.