慢性阻塞性肺疾病合并呼吸衰竭患者应用痰热清注射液治疗的效果及安全性研究

The study on the application effect and safety of Tanreqing injection in treating patients with chronic obstructive pulmonary disease and respiratory failure

目的通过对慢性阻塞性肺疾病合并呼吸衰竭患者使用痰热清注射液进行治疗来研究这种治疗的效果以及其安全性。方法将2013年1月至2014年1月的100例的慢性阻塞性肺疾病合并呼吸衰竭的患者随机的按入院的顺序进行排列,从中随机抽出50例为观察组,50例为对照组。对于对照组中50例患者进行常规的有创的呼吸支持,同时进行解痉、抗感染等等的综合的治疗,而对与观察组的患者则除了进行上述对照组的操作之外还要再使用痰热清注射液进行辅助治疗。记录并比较两组患者的血气的分析结果、有创机械的通气的时间还要分析两组患者的相关的临床症状的表现。结果观察组的临床疗效总有效率为82.0%,对照组的总有效率为44%,观察组比对照组效果更好,差异具有统计学意义(P<0.05)。观察组中的患者产生不良反应的人数少于对照组中产生不良反应的人数。数据的比较有显著性差异(P<0.05)。患者经过治疗后PO2以及PCO2的指标都比治疗前有所改善(P<0.05),且治疗之后观察组的PO2比对照组的指标更高(P<0.05),而PCO2的指标更低(P<0.05),数据的差异具有统计学意义(P<0.05)。观察组的总满意率为84%,而对照组的总满意率为60%。观察组比对照组的效果更好,两组患者总满意率比较有显著性差异(P<0.05)。结论对于慢性阻塞性肺疾病合并呼吸衰竭患者使用痰热清注射液来进行治疗可以有效的改善患者的肺通气的功能,同时还能提高临床的疗效,是临床上用于治疗肺疾病以及呼吸疾病的一种非常重要的辅助的治疗药物。

Objective To research the therapeutic effects and safety of Tanreqing injection in treating patients with chronic obstructive pulmonary disease and respiratory failure. Methods 100 cases of chronic obstructive pulmonary disease and respiratory failure patients in our hospital during January 2013 and January2014 were chose,and they were divided into two groups randomly,50 cases in each group. The 50 patients in control group received routine invasive respiratory support. Antispasmodic, anti- infection and other comprehensive treatment were used. Meanwhile,patients in the observation group used the equal treatment and added the Tanreqing injection as adjuvant therapy. Recorded and analyzed the blood,invasive mechanical ventilation time and the related symptoms of the patients of the two groups. Results The total effective rate of the clinical observation group was 82%,the control group was 44%,the difference was statistically significant（ P〈0. 05）. The number of adverse reaction in was observation group was less than that in the control group. PO2 and PCO2 index were improved after the treatment（ P〈0. 05）. The PO2 index of observation group was higher than the control group,but the PCO2 index was lower than that in the control group（ P〈0. 05）. The total satisfactory rate was 84% in observation group and it was higher than 60% in control group（ P〈0. 05）. Conclusions Tanreqing injection can improve the pulmonary ventilation function and the clinical efficacy of patients with chronic obstructive pulmonary disease combined with respiratory failure. It is an important auxiliary treatment of lung diseases and respiratory diseases in clinic.