复发性多软骨炎患者临床特征分析

Clinical characteristics of patients with relapsing polychodritis

目的 分析复发性多软骨炎（RP）的临床特征,提高对本病的认识.方法 回顾性分析2004年1月至2014年6月期间在北京协和医院住院治疗的131例RP患者的临床症状及实验室检查资料.结果 发病年龄9 ～76（44±13）岁,男女比例1.22∶1.以呼吸系统起病者所占比例最大,为61.8％,其次分别为耳廓（16.0％）、关节软骨（15.3％）、眼部（7.6％）、内耳系统（5.3％）、鼻软骨（4.6％）、皮肤（2.3％）和神经系统（0.8％）.在整个病程中,呼吸系统受累的患者比例最大,占81.7％,其次分别为关节症状（77.9％）、鼻软骨病变（56.5％）、耳廓软骨病变（54.2％）、眼部病变（35.1％）、内耳系统受累（33.6％）和皮肤病变（10.7％）,神经系统和肾脏的病变发生率相对较低,分别占9.2％和1.5％.血白细胞和血小板升高者分别占38.2％和43.5％;红细胞沉降率和C反应蛋白升高者分别占86.3％和82.4％.结论 复发性多软骨炎是一个累及多系统的疾病,临床表现复杂多变,呼吸道是该病最常见的受累部位,且呼吸系统受累是本病预后不良的重要因素.

Objective To analyze the clinical characteristics of relapsing polychodritis （RP）.Methods Clinical features and laboratory data of 131 patients with RP were analyzed retrospectively.Results The average age at onset was （44 ± 14） years （ranging from 9 to 76）.Male to female ratio was 1.22∶ 1.The most common onset symptom was respiratory system symptom （61.8%）,followed by auricle lesions （16.0%）,articular cartilage （15.3%）,ocular region （7.6%）,internal ear system （5.3%）,nasal cartilages （4.6%）,skin （2.3%） and nervous system （0.8%）.During the whole course of the disease,81.7% of the patients endured a respiratory system involvement;77.9% and 56.5% of the patients suffered joint symptoms and nasal cartilages lesions,respectively;the involvement of auricle lesions,ocular region and internal ear system were 54.2%,35.1% and 33.6%.Comparatively,the occurrence rates of skin lesion （10.7%）,neurologic disorder （9.2%） and kidney system lesions （1.5%） were low.Analyzing of the laboratory examination data showed that 38.2% and 43.5% of the patients had an increase in white blood count （WBC） and platelet,86.3% and 82.4% patients showed raised erythrocyte sedimentation rate （ESR） and C-reactive protein （CRP） values.Conclusions RP is a multisystem involvement disease,which has complicated clinical manifestations.Respiratory tract is the most common site involved,and respiratory system involvement is a prediction of unfavourable prognosis.