丹参酮合成生物学研究进展

Research progress of synthetic biology for tanshinones

通过阐明并模拟中药活性成分生物合成的基本规律,人工设计并构建新的、具有特定生理功能的生物系统(药用植物或微生物系统),这种中药合成生物学研究策略,将是一种极具潜力的中药活性成分资源获取方法。丹参酮是丹参中一类具有显著药理活性的二萜,该文系统介绍了丹参酮合成生物学研究进展,旨在为其他中药萜类活性成分研究提供借鉴,为中药资源可持续利用研究提供新的研究策略。

Synthetic biology research methods which design and build a new artificial biological systems （ medicinal plants or micro- organisms system） with specific physiological functions through clarifying and simulating the basic law of the biosynthesis of active com- ponents of traditional Chinese medicine, is considered to be a potential method to produce an abundant resources of bioactive compo- nents. Tanshinones is a kind of diterpene quinone compounds with important pharmacological activities from traditional Chinese medi- cine Salvia miltiorrhiza. This article systematically introduced the research progress of the synthetic biology of S. miltiorrhiza, in order to provide references for studies on other terpenoid bioactive components of traditional Chinese medicines, and give new research strate- gies for the sustainable develooment of traditional Chinese medicine resources.