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丙泊酚和七氟烷对儿童智力发育的影响

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摘要 全身麻醉是否会影响儿童智力发育一直存在争议。近期多种研究显示,全麻药物在未成熟哺乳动物大脑的快速生长期可激发大脑神经元的大量变性凋亡,导致后期的神经发育障碍,表现为行为异常和学习记忆功能减退[1]。这可能与全身麻醉药物通过促使γ-氨基丁酸（γ-aminobutyric acid,GABA）和/或N-甲基-D-天冬氨酸（N-methyl-D-aspartic acid,NMDA）受体突触递质释放.
作者 吕笑侠 金旭东
机构地区 浙江大学医学院附属第四医院麻醉科
出处 《全科医学临床与教育》 2015年第4期423-425,共3页 Clinical Education of General Practice
关键词 智力发育 N-甲基-D-天冬氨酸 儿童 七氟烷 丙泊酚 神经发育障碍 记忆功能减退 γ-氨基丁酸
分类号 R726.1 [医药卫生—儿科]
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全科医学临床与教育
2015年 第4期

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