噬菌体展示技术研究进展

Progress of phage display technique

噬菌体肽库是在噬菌体基因中整合一段编码外源短肽的寡聚核苷酸,该寡聚核苷酸能在噬菌体表面以融合蛋白的形式表达,并获得不同特定长度的小肽集合。目前,噬菌体肽库被广泛应用在蛋白表位的筛选、药物筛选、疫苗研制等方面。

Phage display peptide is a code of exogenous short peptide oligonucleotide integrated in phage genes and expressed in phage surface as a fusion protein with specific different length. Phage peptide library has been maturely applied to epitope mapping analysis, pharmaceutical screening and vaccine development, etc., in present.