摘要
目的检索国内外1997～2014发表的Orexin与癫痫相关文章，探讨Orexin在癫痫发病及治疗中的最新研究进展。方法2014年7在Pubmed、中国知网、万方数据库，以“Orexin”、“癫痫”、“Orexin受体”、“癫痫治疗”等作为检索词，分析Orexin及其受体在癫痫发生、发展及其治疗中的作用。结果检索到相关文献102篇，纳入分析30篇。结果显示Orexin是下丘脑外侧区和穹窿周围的神经元产生的一种兴奋性神经肽，可提高大脑皮层的兴奋性，过度表达能诱导痫性发作。结论Orexin过度表达能诱导痫性发作，抑制Orexin的过度激活对控制癫痫发作有重要的临床价值。
Objective To explore the role of Orexin in pathogenesisepilepsy and treatment of epilepsy based on the literatures published from 1998 to 2014 at home and abroad.Methods Searched the literatures from the online database including Pubmed, CNKI and Wanfang Datebases in July 2014. The words Orexin, epilepsy, Orexin receptor, epilepsy treatment were used as search terms. Analyze the effect Orexin and its receptors in the oc- currence, development and trealment of epilepsy. Results 102 related literatures were retrieved and 30 were a- dopted into analysis.It was showed Orexin is a kind of excitatory neuropeptides and it can increase the excitability of cerebral cortex. Epilepsy can be induced by excessive expression of Orexin.Conclusion Excessive expression of Orexin can cause epileptic seizure. Inhibiting the excessive activation of Orexin neurons is of important to control seizures in clinical practices.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2015年第7期669-671,共3页
Chinese Journal of Behavioral Medicine and Brain Science
基金
上海市卫生局基金项目（20124258）
