皮肤组织工程中胶原三维多孔支架的研究现状

Research Progress of Collagen-based Three-dimensional Porous Scaffolds Used in Skin Tissue Engineering

胶原是一种天然生物医学材料,以胶原为基底制备的三维多孔支架在皮肤组织工程中具有广泛应用。但是胶原三维多孔支架作为人工皮肤存在机械性能差、供源不足、排异反应等一系列问题,限制了其在皮肤组织工程中的进一步应用。为改善这种状况,可以通过交联、共混等方式提高支架机械性能,结合细胞培养、负载生长因子等技术实现结构、功能高度仿生,此外为避免动物源胶原的安全隐患问题,使用重组胶原制备皮肤替代物成为本领域的研究热点。本文综述了皮肤组织工程中胶原三维多孔支架的研究现状。

Collagen is a kind of natural biomedical material and collagen based three-dimensional porous scaffolds have been widely used in skin tissue engineering. However, these scaffolds do not meet the requirements for artificial skin substitutes in terms of their poor mechanical properties, short supply, and rejection in the bodies. All of these factors limit their further application in skin tissue engineering. A variety of methods have been chosen to meliorate the situation, such as cross linking and blending other substance for improving mechanical properties. The highly biomimetic scaffolds either in structure or in function can be prepared through culturing cells and loading growth factors. To avoid the drawbacks of unsafety attributing to animals, investigators have fixed their eyes on the recombinant collagen. This paper reviews the the progress of research and application of collagen-based 3-dimensional porous scaf- folds in skin tissue engineering.