摘要
目的 研究干扰素-β与多发性硬化症疗效之间的关系。方法 检索纳入9篇（从2001~2010年）国际和国内有关干扰素治疗多发性硬化症的文献,应用随机效应模型和固定效应模型进行综合的定量分析,软件为Rev Man5.0。结果 干扰素-β治疗多发性硬化症复发的疗效的RR值为0.79,95%CI（0.66~0.94）;发热症状的RR值为2.45,95%CI（1.57~3.80）,P〈0.01;注射部位反应的RR值为5.11,95%CI（3.77~8.09）,P〈0.01。结论 干扰素-β治疗多发性硬化症,可明显缓解发病情况,可以改善预后。
Objective To research the relationship between interferon-β and multiple sclerosis. Methods 9 papers （since 2001 to 2010） about international and domestic literature on interferon therapy for multiple sclerosis were retrieval included.Random effect model and fixed effect model were applied to analyze the comprehensive quantitative with RevMan5.0. Results The RR value of interferon- β in the treatment of multiple sclerosis was 0.79,95%CI was 0.66-0.94;Fever symptoms ： RR=2.45,95%CI（1.57-3.80）,P 〈0.01.Injecting site reaction ： RR=5.11,95 % CI（3.77-8.09）,P 〈 0.01. Conclusion Interferon- β therapy can obviously alleviate the incidence,can improve the prognosis
出处
《中国医药科学》
2015年第12期27-30,共4页
China Medicine And Pharmacy
