子宫内膜癌术中冰冻和术后石蜡病理诊断符合率及其影响因素

Diagnostic coincidence rate and influencing factors of intraoperative biopsy and postoperative paraffin pathology in endometrial carcinoma

目的探讨子宫内膜癌术中冰冻和术后石蜡病理诊断符合率及其影响因素。方法选取2013年7月~2014年7月来我院就诊的术前病理诊断为子宫内膜癌患者75例,观察及比较采用术中冰冻切片和术后石蜡切片病理诊断子宫内膜癌患者的细胞级别和病变肌层浸润深度指标。结果随着组织级别增加,术中冰冻切片与术后石蜡病理诊断符合率增加。Ⅰ级、Ⅱ级、Ⅲ级术中冰冻切片与术后石蜡病理诊断病变肌层浸润深度的符合率依次为32.14%、86.05%和100.00%,差异有统计学意义(P<0.05)。术中冰冻与术后石蜡病理比较,绝经后子宫内膜癌患者和X线钼靶多发钙化点减少,其判断组织学级别的准确性明显提高(P<0.05)。结论冰冻病理在诊断子宫内膜癌肌层浸润深度上符合率较高,但在细胞级别的诊断上有一定局限。

Objective To explore the diagnostic coincidence rate and influencing factors of intraoperative biopsy and postoperative paraffin pathology in endometrial carcinoma. Methods 75 cases with preoperative pathological diagnosis of endometrial carcinoma from 2013 July to 2014 July in our hospital were selected, and the intraoperative biopsy and postoperative paraffin pathology were observed and compared on the cellular level and depth of myometrial invasion in patients with endometrial carcinoma. Results As the organization level increase, the diagnostic coincidence rate of intraoperative biopsy and postoperative paraffin pathology increase.In the diagnosis of depth of my0metrie^l invasion, the diagnosis coincidence rate of grade I, II and III by intraoperative biopsy and postoperative parafin pathology was 32.14%, 86.05% and 100.00%, the difference was statistically significant （P 〈 0.05）. Compared with postoperative paraffin pathology,the number of post-menopause endometrial carcinoma patients and multiple enhanced（P〈0.05）.Conclusion The coincidence rate of depth of depth of myometrial invasion in endometrial carcinoma by intraoperative biopsy pathology is high,but there is certain limitationin in the diagnosis of cellular level.