双环醇和多烯磷酯酰胆碱治疗甲亢性肝损伤疗效观察

Clinical Effect Observation of Bicyclol and Polyene Phosphatidylcholine in the Treatment of Liver Injury Induced by Hyperthyroidism

目的:观察双环醇片和多烯磷酯酰胆碱胶囊治疗甲亢性肝损伤临床疗效和安全性。方法:112例甲亢性肝损伤患者随机分为两组,在常规使用甲巯咪唑治疗同时,观察组56例加用双环醇片,对照组56例加用多烯磷酯酰胆碱胶囊,疗程均为4周。比较两组患者治疗前后丙氨酸转氨酶(ALT)、血清天冬氨酸转氨酶(AST)、总胆红素(TBIL)、碱性磷酸酶(ALP)等指标的变化,观察两组疗效与药品不良反应。结果:治疗后两组ALT、AST、TBIL、ALP水平均较治疗前显著下降(P<0.05),且观察组ALT、AST水平明显低于对照组(P<0.05),而TBIL、ALP水平无差异(P>0.05)。观察组总有效率明显高于对照组(P<0.05)。两组药品不良反应均较轻微。结论:双环醇片能有效治疗甲亢性肝损伤,且疗效优于多烯磷酯酰胆碱。

Objective： To observe the clinical efficacy and safety of bicyclol and polyene phosphatidylcholine in the treatment of liver injury induced by hyperthyroidism. Methods： Totally 112 cases of hyperthyroidism patients were randomly divided into two groups, and both groups were treated with antithyroid drug methimazole. The 56 patients in the treatment group were orally treated with bicyclol, and the other 56 patients in the control group received polyene phosphatidylcholine capsules orally. The changes of liver function were compared before and after the d-week treatment, including the level of alanine aminotransferase （ ALT）, aspartate aminotransferase （AST）, total bilirubin （TBIL） and alkaline phosphatase （ALP）. The efficacy and adverse reactions were also observed. Results ： There was no difference in the levels of ALT, AST, TBIL and ALP in both groups before the treatment （ P 〉 0.05 ）, while the levels were all decreased significantly in both groups after the treatment （P 〈 0.05）. Compared with those of the control group, ALT and AST levels of the treatment group were decreased significantly after the treatment （P 〈 0.05 ）, and the total effective rate of the treatment group was higher than that of the control group with statistical significance （ P 〈 0.05）, while no statistically significant difference was shown in the levels of TBIL and ALP （P 〉 0.05 ）. No drug-related adverse events were shown during the treatment. Conclusion： Bicyclol is effective and reliable in the treatment of liver injury induced by hyperthyroidism, and the clinical efficacy is remarkable when compared with that of polyene phosphatidylcholine.