基于纵向监测队列的2型糖尿病与甲状腺结节的关联性

Type 2 diabetes mellitus associated with thyroid nodules: a longitudinal health check-up cohort study

目的研究2型糖尿病与甲状腺结节之间的关系,探讨影响甲状腺结节的危险因素,为预防甲状腺结节的发生提供参考。方法构建多中心健康查体人群队列,体检者进入队列时均无甲状腺结节,共有15 528人进入随访队列,应用广义估计方程(GEE)模型研究2型糖尿病与甲状腺结节之间的关联。结果2010年结束随访时共检出甲状腺结节患者1 592人,2型糖尿病组和健康体检组发病密度分别为36.33/1 000人年和28.55/1 000人年,两组之间差异有统计学意义(χ2=14.80,P<0.001)。在控制了其他潜在的混杂因素后,多因素GEE模型发现2型糖尿病与甲状腺结节之间具有关联性(RR=1.299,P=0.001)。结论2型糖尿病是甲状腺结节的独立危险因素。

Objective To construct a large-scale longitudinal health check-up cohort in urban Chinese population to highlight and confirm the association between type 2 diabetes mellitus and thyroid nodules,to explore the possible factors affecting the formation of thyroid nodule,and to provide guidance for the prevention of thyroid nodules. Methods A longitudinal cohort with 15 528 participants was established based on the routine health check-up systems,and generalized estimating equation（ GEE） model was used to detect the association between type 2 diabetes mellitus and thyroid nodules. Results A total of 1 592 cases of thyroid nodules occurred during the 6-year follow-up. The incidence densities of type 2 diabetes mellitus group and healthy group were 36. 33 per 1 000 person-years and 28. 55 per 1 000person-years respectively. The difference was statistically significant（ χ^2 = 14. 80,P〈0. 001）. Our data confirmed and clarified the association between type 2 diabetes mellitus and thyroid nodules（ RR = 1. 299,P = 0. 001） after adjusting other potential confounding factors. Conclusion Type 2 diabetes mellitus is associated with thyroid nodules in urban Chinese population.