路易体痴呆百年史

A 100-year history of dementia with Lewy bodies

1912年,德国病理学家Frederick Henry Lewy在帕金森病患者大脑神经元中检出一种异常蛋白小体;1919年,前苏联病理学家Konstantin Tretiakoff将其命名为"路易小体";1961年,日本学者Okazaki证实痴呆的发生发展与皮质型路易小体相关;1980年,Kenji Kosaka提出"路易体病"的概念;至1995年,首届国际路易体痴呆研讨会将弥漫性路易体病、路易小体型老年痴呆、阿尔茨海默病路易小体变异型和大脑型路易体病统一命名为"路易体痴呆",并于2003年对其诊断标准进行重新修订,2005年发表于Neurology后应用于临床实践。

It takes more than one hundred years to understand dementia with Lewy bodies （DLB）. Frederick Henry Lewy, a Germany doctor who studied the neuropathology of Parkinson＇s disease （PD） at Munich University, described eosinophilic intracytoplasmie inclusions in the dorsal vagal nuclei and substantia innominata of PD brains in 1912 for the first time. These inclusions were later named as ＂Lewy body （LB）＂ by a Russian neuropathologist Konstantin Tretiakoff in 1919. A Japanese researcher, Okazaki, correlated dementia to cortical LB in 1961. Kosaka proposed the term ＂Lewy body disease （LBD）＂ for the first time in 1980. Subsequently, more and more researchers delivered case reports and detailed classification of LBD. In 1995, the first Consortium on DLB International Workshop made the unitary denomination of this disease entity and established consensus guidelines for the clinical and pathological diagnosis of DLB. The diagnostic criteria were revised in 2003. Though the history of DLB study is similar to Alzheimer＇s disease （AD）, DLB is still less recognized and needs further research.