癌痛示范病房创建对麻醉性镇痛药物临床应用的影响

Effect of pain management ward on clinical application of narcotic analgesic drugs

目的调查麻醉性镇痛药物以及癌痛三阶梯用药原则在癌痛规范化治疗示范病房(以下简称"示范病房")成立前后癌痛患者中的应用情况。方法通过对2012年和2013年肿瘤内科住院患者的麻醉性镇痛药物的用量以及用药频度进行统计分析,同时将使用的麻醉性镇痛药品换算成口服吗啡的等效剂量进行对比,结合临床分析麻醉性镇痛药物的临床应用情况。结果 2013年肿瘤内科癌痛用药较2012年明显增加,口服制剂用量明显增加,尤其是具有很好生物利用度的缓释剂型使用量明显增加。盐酸哌替啶注射液2013年没有再被使用。结论成立示范病房以后,麻醉性镇痛药物使用基本合理,用药情况符合WHO提出的三阶梯用药原则,癌痛规范化治疗有所成效。

Objective To investigate the application of narcotic analgesic drugs and 3-step drug therapy for pain relief in cancer patients before and after the establishment of the pain management ward. Methods The consumption amount and DDDs of narcotic analgesics in the oncology ward during 2012 -- 2013 collected from hospital information system were analyzed and also converted into the equivalent doses of oral morphine to be compared. Results In 2013, the pain relief medication was significantly increased compared with that in 2012, the oral preparation increased obviously, and especially the sustained-release dosage form with good bioavailability increased significantly. Pethidine hydrochloride injection in 2013 was no longer used. Conclusion After the establishment of the pain management ward, narcotic analgesic drug use is more reasonable and medication administration is consistent with the principles of 3 steps proposed by the WHO. The standardized treatment of cancer pain is effective.