高尿酸血症与老年人认知功能障碍的相关性研究

Study on correlation between hyperuricemia and cognitive dysfunction in elderly people

目的探讨老年人认知功能障碍与高尿酸血症的相关性。方法选取2010年1月-2014年1月在深圳市宝安区人民医院（以下简称＂我院＂）住院或门诊就医的老年认知功能障碍患者200例,分为轻度认知障碍组100例,痴呆组100例,另选取我院同期健康体检老年人100例作为对照组,比较3组血尿酸水平,并对可能影响认知功能的因素,如高尿酸血症以及年龄、受教育程度、吸烟史、饮酒史、高血压、血糖、血脂等指标引入Logistic回归分析,判断高尿酸血症对认知功能障碍的影响。结果轻度认知功能障碍组[（365.9±38.7）μmol/L]与痴呆组[（421.3±43.0）μmol/L]血尿酸水平高于对照组[（237.5±40.2）μmol/L],痴呆组血尿酸水平高于轻度认知功能障碍组,差异均有统计学意义（均P〈0.05）。Logistic回归分析显示,高尿酸血症是认知功能障碍的危险因素（OR=2.944,P〈0.05）。结论高尿酸血症是老年人认知功能障碍的危险因素,且认知功能障碍程度与血尿酸水平相关。

Objective To explore correlation between cognitive dysfunction and hyperuricemia in elderly people.Methods 200 cases of elderly patients in Bao＇an District People′s Hospital of Shenzhen City（＂our hospital＂ for short）from January 2010 to January 2014 were selected and divided into 2 groups, with 100 cases in mild cognitive dysfunction group and 100 cases in dementia group. Another 100 healthy elderly people with physical examination in our hospital were selected as control group. The blood uric acid levels of the three groups were compared, and possible factors related with cognitive function like hyperuricemia, age, education level, smoking history, drinking history, high blood pressure, blood glucose and blood lipid were analyzed by Logistic regression in order to determine effects of hyperuricemia on cognitive dysfunction. Results The blood uric acid level in mild cognitive dysfunction group [（365.9±38.7） μmol/L]and dementia group [（421.3±43.0） μmol/L] was higher than that in control group[（237.5±40.2） μmol/L] respectively, and the blood uric acid level in dementia group was higher than that in mild cognitive dysfunction group, with statistically significant difference（all P〈0.05）. Logistic regression showed that hyperuricemia was the risk factor of cognitive dysfunction（OR = 2.944, P〈0.05）. Conclusion Hyperuricemia is the risk factor of cognitive dysfunction in elderly people, and the degree of cognitive dysfunction relates with uric acid level.