小剂量辛伐他汀对心肾综合征患者心、肾功能的影响

Effect of low-dose Simvastatin on cardiac and renal function in patients with cardiorenal syndrome

目的观察心肾综合征（CRS）患者服用小剂量辛伐他汀后心、肾功能的变化。方法选择2012年1-12月在东南大学医学院附属南京市胸科医院门诊和病房住院的CRS患者56例,患者每晚睡前服用辛伐他汀10 mg,连续服用8周。入选后次日清晨及治疗第8周清晨抽取空腹静脉血,采用全自动生化分析仪检测患者空腹血糖（FBG）、总胆固醇（TC）、低密度脂蛋白-胆固醇（LDL-C）、高密度脂蛋白-胆固醇（HDL-C）、三酰甘油（TG）、尿素氮（BUN）、肌酐（Cr）浓度;根据纽约心功能分级（NYHA）及心脏超声评判患者心功能。结果治疗前后患者FBG、TC、LDL-C、HDL-C、左心房内径、左心室射血分数比较,差异均无统计学意义（P〉0.05）;治疗后NYHA分级、BUN、Cr、评估的肾小球滤过率及左室舒张末期内径与治疗前比较,差异均有统计学意义（P〈0.05或P〈0.01）。结论小剂量辛伐他汀能够改善CRS患者的心、肾功能。

Objective To investigate the effects of low dose Simvastatin on cardiac and renal function in patients with cardiorenal syndrome（CRS）. Methods From January to December 2012, 56 patients with CRS were enrolled in Nanjing Chest Hospital, Southeast University School of Medicine and treated with Simvastatin（10 mg per night） for 8 weeks.Fasting blood-glucose（FBG）, serum total cholesterol（TC）, low-density lipoprotein（LDL-C）, high-density lipoprotein（HDL-C）, triglycerides（TG）, blood urea nitrogen（BUN）, and creatinine（Cr） levels of patients were measuredby automatic biochemical analyzer after being selected and the 8th week after treatment. Heart function was evaluated according to New York Heart Association Classification（NYHA） and echocardiography. Results FBG、TC、LDL-C、HDL-C、LA、LVEF before and after treatment had no statistically significant difference（P〉0.05）; compared with before treatment, NYHA classification, BUN, Cr and the average left ventricular end diastolic diameter, the average left ventricular eject fraction and estimated glomerular filtration rate after treatment had statistically significant differences（P〈0.05 or P〈 0.01）. Conclusion Low-dose Simvastatin can improve cardiac and renal function of patients with CRS.