氯化钾注射液致输液反应原因分析及预防对策

Reasons of Transfusion Response and Prevention Countermeasures of Potassium Chloride Injection

目的探讨氯化钾注射液致输液反应的原因,指导临床输液,避免输液反应的发生。方法对近两年本院临床科室送检的17例氯化钾注射液致输液反应报告进行分析总结,模拟临床用药配伍,对氯化钾注射液与10%GS、5%GNS、0.9%NS及平衡液配伍前后的质量、内毒素、微粒、理化性质、活菌等(致输液反应发生的原因)进行检测。结果氯化钾注射液与多种输液配伍前后的质量、内毒素、微粒、理化性质、活菌等的监测与配伍前无明显差别。结论氯化钾注射液致输液反应与:大输液的质量,添加药物的质量和剂量;输液器的质量;输液速度;输液环境;患者因素等有关,应引起重视。

OBJECTIVE To guide clinical transfusion and avoid the occurrence of transfusion response through investigating the reasons of the potassium chloride injection infusion response. METHODS A total of 17 cases of intravenous transfusion reaction about the quality,endotoxin,particles,physicochemical properties,viable cells and other aspects of the hospital in the past 2 years were analyzed. RESULTS There was no significant difference in the quality,endotoxin,particles,physicochemical properties,viable cells between potassium chloride injection and its mixture. CONCLUSION Potassium chloride injection transfusion response was related to： the quality of a large infusion and the dose of a drug,the quality of infusion,infusion rate,infusion environment,and patients＇ factors.