南京地区31家医院2011-2013年抗抑郁药利用分析

Analysis of the Utilization of Antidepressant Drugs in 31 Hospitals of Nanjing During 2011 to 2013

目的:为抗抑郁药的临床合理使用提供参考。方法:回顾性分析南京地区31家医院2011-2013年的抗抑郁药使用情况,统计限定日剂量、用药频度、日均费用、年平均增长率和排序比值。结果:南京地区医院2011-2013年抗抑郁药物的销售金额以及DDDs逐年上升,帕罗西汀3年来持续占据用药金额榜首。根据DDDs排序,选择性5-羟色胺再摄取抑制剂(SSRI)占据榜首,5-羟色胺和去甲肾上腺素再摄取抑制剂与特异性5-羟色胺抑制剂分据第2、3位。结论:南京地区医院的抗抑郁药使用基本合理,以氟伏沙明、氟西汀、西酞普兰、舍曲林及帕罗西汀为代表的SSRI类抗抑郁药仍是医院的一线用药。

OBJECTIVE：To provide reference for rational use of antidepressant drugs in the clinic. METHODS：The utilization of antidepressant drugs in Nanjing during the period of 2011-2013 were analyzed statistically in respect of DDD,DDDs,DDC,average annual growth rate and ratio of ranking method. RESULTS：From 2011 to 2013,consumption sum and DDDs of antidepressant drugs increased year by year in 31 hospitals of Nanjing;paroxetine occupied the first place in the list of consumption sum. Selective serotonin reuptake inhibitors（SSRI）got the top place ranked by DDDs,followed by serotonin/norepinephrine reuptake inhibitors and special serotonin antidressant. CONCLUSIONS：The application of antidepressant drugs in Nanjing area is basically reasonable. SSRIs,such as fluvoxamine,fluoxetine,citalopram,sertraline and paroxetine,are still the first-line antidepressant drugs recent years in Nanjing.