α干扰素对根治性肝切除术后患者远期生存率及肿瘤复发的影响

Effects of α Interferon on Long-term Survival Rate and Tumor Recurrence After Radical Hepatic Resection

目的：探讨根治性肝切除术后运用α干扰素（IFN-α）对患者近期生存率及肿瘤复发的影响。方法：选取根治性肝切除术的原发性肝细胞癌患者104例,按患者意愿分为观察组（62例）和对照组（42例）,观察组术后4~6周采取IFN-α治疗18个月,对照组术后进行常规治疗,比较两组患者术后总生存率以及术后无瘤生存率。结果：观察组患者术后1、3、5年生存率分别为82.26%（51/62）、61.29%（38/62）、24.19%（15/62）,对照组分别为41.94%（26/62）、28.57%（12/42）、9.52%（4/42）,两组比较差异有统计学意义（P〈0.05）;观察组患者术后1、3、5年无瘤生存率分别为61.29%（38/62）、40.32%（25/62）、17.74%（11/62）,对照组分别为43.55%（27/62）、22.58%（14/62）、0（0/62）,两组比较差异有统计学意义（P〈0.05）。结论：根治性肝切除术后运用IFN-α能够显著抑制术后肿瘤的复发,提高患者的远期生存率,值得临床深入研究。

OBJECTIVE：To investigate the effect of α-interferon on long-term survival rate and tumor recurrence after radical hepatic resection. METHODS：104 patients with primary hepatocellular carcinoma underwent radical hepatic resection were divided into observation group（62 cases）and control group（42 cases）. Observation group was treated with IFN-α for 18 months 4-6 weeks after surgery;control group received rountine treatment. Total survival rate and disease-free survival rate after surgery were compared between 2 groups. RESULTS：In observation group after surgery,1-year survival rate was 82.26%（51/62）,3-year survival rate 61.29%（38/62）,and 5-year survival rate 24.19%（15/62）;in control group after surgery,1-year survival rate was 41.94%（26/62）,3-year survival rate 28.57%（12/42）and 5-year survival rate 9.52%（4/42）;there was statistically significant difference in postoperative survival rate between 2 groups（P〈0.05）. In observation group after surgery,1-year disease-free survival rate was61.29%（38/62）,3-year disease-free survival rate 40.32%（25/62）,and 5-year disease-free surial rate 17.74%（11/62）;in control group after surgery,1 year disease-free survival rate was 43.55%（27/62）,3 year disease-free survival rate 22.58%（14/62）,and5-year disease-free surial rate was 0（0/62）;there was statistically significant difference in postoperative disease-free survival rate between 2 groups（P〈0.05）. CONCLUSIONS：The application of α-interferon after radical hepatic resection can significantly inhibit the recurrence of postoperative tumor,improve the long-term survival rate,and is worthy of clinical research.