隔药饼灸联合姜黄素治疗克罗恩病的疗效观察

Efficacy Observation of Herbs-partitioned Moxibustion Combined with Curcumin in the Treatment of Crohn's Disease

目的:观察隔药饼灸联合姜黄素治疗克罗恩病的临床疗效及安全性。方法:选取确诊为轻、中度克罗恩病患者80例,按照随机数字表法分为观察组和对照组,各40例。两组患者均采用柳氮磺吡啶等西药治疗,对照组患者在西药治疗基础上采用姜黄素治疗,观察组患者在西药治疗基础上采用隔药饼灸联合姜黄素治疗,2个月后观察两组患者治疗后的疗效、不良反应、并发症。结果:对照组和观察组总有效率分别为87.50%和95.00%,观察组优于对照组,差异有统计学意义(P<0.05);对照组患者和观察组患者治疗后不良反应发生率为22.50%和7.50%,观察组明显低于对照组,差异有统计学意义(P<0.01);对照组患者和观察组患者治疗后并发症发生率为22.50%和7.50%,观察组明显低于对照组,差异有统计学意义(P<0.01)。结论:隔药饼灸联合姜黄素治疗克罗恩病疗效显著,可降低不良反应与并发症的发生率。

OBJECTIVE：To observe the clinical efficacy and safety of herbs-partitioned moxibustion combined with curcumin in the treatment of Crohn＇s disease. METHODS：80 patients with mild and middle Crohn＇s disease were randomly divided into observation group and control group with 40 patients in each group. Both groups were given western medicine treatment,such as sulfasalazine;control group was additionally given curcumin,and observation group were given curcumin combined with herbs-partitioned moxibustion. 2 months later,Therapeutic efficacy,ADR and complications of 2 groups were observed after treatment. RESULTS：The total effective rate of control group and observation group were 87.50% and 95.00%,respectively;that of observation group was better than that of control group,with statistical significance（P〈0.05）. The incidence of ADR in control group and observation group were 22.50% and 7.50% respectively;that of observation group was significantly lower than that of control group,with statistical significance（P〈0.01）. The incidence of complications in control group and observation group were 22.50%and 7.50%,respectively;that of observation group was significantly lower than that of control group,with statistical significance（P〈0.01）. CONCLUSIONS：The clinical efficacy of herbs-partitioned moxibustion combined with ccurcumin is effective in the treatment of Crohn＇s disease,and can reduce the incidence of ADR and complications.