类风湿关节炎相关肺间质病变的危险因素分析

Analysis of risk factors for rheumatoid arthritis-related interstitial lung disease

目的通过分析与探讨类风湿关节炎相关肺间质病变的危险因素,为临床上预防该种疾病提供相关依据。方法 97例类风湿关节炎患者作为研究对象,其中单纯类风湿关节炎患者(单纯组)53例,类风湿关节炎相关肺间质病变患者(合并组)44例,对两组患者的临床资料进行对比分析。结果合并组患者的发病年龄、病程、抗环瓜氨酸肽(CCP)抗体值、吸烟率、类风湿因子(RF)、疾病活动性评分均明显高于单纯组,差异均有统计学意义(P<0.05)。结论类风湿关节炎患者年龄越大、病程越长、有吸烟史、疾病活动率越高、抗CCP抗体值越高越容易发生肺间质病变,应早期检查、早期诊治,以降低死亡率,促进患者早日康复。

Objective To analyze risk factors for rheumatoid arthritis-related interstitial lung disease, in order to provide related reference for clinical prevention. Methods Among the 97 patients with rheumatoid arthritis as study subjects, there were 53 cases with single rheumatoid arthritis（single group） and 44 cases with rheumatoid arthritis-related interstitial lung disease（complicated group）. Clinical data of the two groups were comparative analyzed. Results The complicated group had much higher onset age, course of disease, anti-cyclic citrullinated peptide（CCP） antibody value, smoking rate, rheumatoid factors（RF）, and disease activity score than the single group, and their differences all had statistical significance（P0.05）. Conclusion Interstitial lung disease occurs easily in rheumatoid arthritis patients with old onset age, long course of disease, smoking history, high disease activity and anti-CCP antibody value. Early examination and diagnosis are necessary for reducing mortality and accelerating rehabilitation of patients.