尿激酶脑室持续灌洗联合腰大池引流术治疗脑室出血及术后继发脑积水

Treatment of intraventricular hemorrhage and secondary hydrocephalus by external ventricular drainage with continuous infusing urokinase ＆ lumbar cistern drainage

目的探讨尿激酶脑室持续灌洗联合腰大池引流能否降低脑室出血术后脑积水的发病率。方法155例患者共分3组，A组：单纯行侧脑室外引流（60例），B组：侧脑室外引流联合腰夫池引流（50例），c组：尿激酶脑室持续灌洗联合腰大池引流（45例）。采用，检验分析3组脑积水发病率之问的差异。结果3组脑积水发病率差异有统计学意义（x2=6．568，P〈0．05），3组脑积水发病率分别为38．3％、28．0％、15．6％，经Bonferroni方法校正后，A、C组之间差异有统计学意义（P〈0．05）。结论尿激酶脑室灌洗联合腰大池引流可以显著降低脑室出血后脑积水的发病率。

Objective To investigate whether it can lower the incidence of hydrocephalus in intra- ventricular hemorrhage （IVH） by external ventricular drainage with continuous infusing urokinase ＆ the lumbar cistern drainage. Methods 155 patients with the clarified diagnosis of IVH were retrospectively studied, and divided into three groups： A, external ventricular drainage （60 cases） ; B, external ventricu- lar drainage combined with lumbar cistern drainage group （50 cases） , and C, external ventricular drainage with continuous infusing urokinase ＆ the lumbar cistern drainage group （45 cases）. The incidence of hy- drocephalus was statistically analyzed in all three groups. Results There was significant difference in tile incidence of hydrocephalus moong three groups （38. 3% , 28.0% and 15.6% ）. After correction by Bonferroni method, there was significant difference between group A and group C （ P 〈 0. 05 ）. Conclusion External ventricular drainage with continuous infusing urokinase ＆ the lumbar cistern drainage can dramatically lower the incidence of hydrocephalus following IVH when applied reasonably.