口腔颌面部良性肿瘤发病影响因素的病例-对照研究

Influencing factors for oral-maxillofacial benign tumors：a case-control study

目的：探讨口腔颌面部良性肿瘤发病的影响因素。方法病例组来源于2010年9月至2015年1月于福建某医院确诊的口腔颌面部良性肿瘤新发病例113例。同期选取符合标准的社区人群作为对照组，共584名。通过问卷调查收集研究对象的人口学特征、吸烟史、饮酒史、饮食习惯、口腔卫生情况、肿瘤家族史等，应用非条件logistic回归模型分析探讨相关因素与口腔颌面部良性肿瘤的关系。结果多因素分析结果显示，口腔颌面部良性肿瘤的危险因素有：吸烟指数〉1000、18岁前被动吸烟、开始戴假牙年龄（35~55岁）及高血压，其OR（95%CI）值分别为14.63（3.88~55.13）、2.34（1.19~4.62）、2.35（1.17~4.73）、3.46（1.71~7.00）；保护因素有：进食肉类≥1次/d、进食水果、服用保健品、补充维生素片，刷牙频率＆gt;1次/d及进行口腔检查≥5年/次，其OR（95%CI）值分别为0.22（0.07~0.70）、0.18（0.08~0.41）、0.32（0.11~0.88）、0.22（0.07~0.73）、0.28（0.16~0.48）、0.28（0.13~0.60）。结论禁止吸烟、减少18岁前被动吸烟、规律的食用肉类、水果、保健品、维生素片以及定期检查口腔卫生有助于减少口腔颌面部良性肿瘤的发生。

Objective To investigate the clinical influence factors of oral-maxillofacial benign tumors. Methods We conducted a case-control study with 113 cases newly diagnosed primary oral-maxillofacial benign tumors and 584 cases controls from a hospital in Fujian from September 2010 to January 2015. Epidemiological data were collected by in-person interviews using a standard questionnaire. The contents of the questionnaire included demography character, history of tobacco smoking and alcohol drinking, dietary habits, oral hygiene status, family history of cancer, etc. Unconditional logistic regression was used to research the relationship between the factors and oral-maxillofacial benign tumors. Results Multivariable analysis showed that risk factors of oral-maxillofacial benign tumors included： cigarette smoking index above 1 000, passive smoking before the age of 18, age of wearing bad prosthesis between 33 to 55 years old and high blood pressure; the corresponding OR（95%CI） values were 14.63 （3.88-55.13）, 2.34 （1.19-4.62）, 2.35 （1.17-4.73）, 3.46（1.71-7.00）, respectively; Protective factors included： regularly intake of meat above 1 time/day, fruits, health care products and vitamin tablets, brushing teeth above 1 time per day and oral examination above 5 years/time, the corresponding OR（95%CI） values were 0.22 （0.07-0.70）, 0.18 （0.08- 0.41）, 0.32 （0.11- 0.88）, 0.22 （0.07- 0.73）, 0.28 （0.16-0.48）, 0.28 （0.13-0.60）, respectively. Conclusion Abstinence from tobacco smoking, reduce passive smoking before the age of 18, regularly intake of meat, fruits, health care products and vitamin tablets, and oral examination at regular time＆amp;nbsp;might have impact on the incidence of oral-maxillofacial benign tumors to a certain extent.