达体朗与丙咪嗪治疗抑郁症的对照研究

A control study of tatinol and imipramine in the treatment of depression.

目的 观察达体朗治疗抑郁症的疗效和安全性。方法 随机将 6 0例抑郁症患者分为达体朗组 (30例 )和丙咪嗪组 (30例 )。疗程 6周。采用汉密尔顿抑郁量表 (HAMD)和副反应量表 (TESS)在治疗前和治疗后第 1、2、4、6周末评定药物疗效和副反应。结果 两组疗效无显著差异 ,HAMD总分及各因子分从疗后 2周～ 6周均较治疗前显著降低 ,两组间无显著性差异 ;治疗结束时TESS评分达体朗组显著低于丙咪嗪组。结论 达体朗治疗抑郁症疗效好 ,副反应少 ,服用方便、安全 ,可首选使用。

Objective To study the efficacy and safety of tatinol in the treatment of depression.Method 60 depressed patients were randomized into tatinol group(n=30) and imipramine(n=30) and studied for 6 week.HAMD and TESS were used to assess the efficacy and side effects before and 1st week,2nd week,4th week and 6th week after the treatment.Results There was no significant difference in efficacy between the two groups.HAMD scores and the factor scores from 2nd week to 6th week decreased dramatically as compared to pretreatment,no significant difference was observed between the two groups.After the trial the TESS scores in tatinol group were significantly lower than that of imipramine group.Conclusion Tatinol was an effective,convenient and safe treatment in depression.It had few side effects and can be a first drug choice.