斯奇康配合人参蛤蚧散治疗慢性阻塞性肺病缓解期的临床观察

Clinical Observation of Siqikang combined with Renshen Gejie Powder in the treatment of Chronic Obstructive Pulmonary Disease of Remission

目的讨论斯奇康配合人参蛤蚧散治疗慢性阻塞性肺病缓解期的临床疗效。方法将66例慢阻肺缓解期患者随机的分为两组,治疗组34例给予肌注斯奇康和人参蛤蚧散口服,时照组给予多索茶碱胶囊,观察记录3年以来慢阻肺急性发作的次数、病程、住院天数,进行统计分析。结果治疗组与对照组比较,3年期间急性发作的次数逐年减少,发作时的症状逐年减轻,持续的天数也明显少于对照组,住院次数减少。肺功能检测,治疗组治疗后肺功能64%的患者基本稳定在干预治疗的水平,另有26%的患者,肺功能下降的幅度也较对照组小,还有10%的患者,肺功能情况与对照组无明显差异。免疫学检测,治疗组经斯奇康配合人参蛤蚧散治疗后,与之前进行对比,T细胞亚群中CD4+明显升高,CD8+明显降低,从而CD4+/CD8+比值显著升高。结论斯奇康配合人参蛤蚧散能有效地提高患者的免疫能力和纠正氧化/抗氧化失衡,大大减少了慢阻肺急性发作的次数和病程,即使发作也能得到有效的控制,提高了患者的生存生活质量。

Objective To discussthe clinical effect of Siqikang combined with Renshen Gejie powder in the treatment of chronic obstruc-tive pulmonary disease of remission. Methods 66 patients with chronic obstructive pulmonary disease of remission were randomly divided into two groups. In the treatment group, 34 patients were given intramuscular injection of BCG-PSN and Renshen Gejie powder. The control group was given Doxofylline capsule. The slow resistance the number of pulmonary exacerbations and duration of hospital stay of three years were recorded and analyzed. Results Comparing the treatment group with the control group, the number of exacerbations during the3-year declined every year, the onset of symptoms reduced each year, the number of days duration was significantly less than that of the control group, and the number of hospitalizations reduced. After treatment, pulmonary function of 64 % patients stayed in the basically stable treatment of intervention level, the decrease in pulmonary function of 26 % patients was smaller than that of the control group, and pul-monary function of 10% patients had no significant difference between the two groups. In immunological detection, after received Siqikang combined with Renshen Gejie powder, in the treatment group, CD4^＋in T cell subsets increased, and CD8^＋decreased, thereby the ratio of CD4^＋/ CD8^＋was significantly increased. Conclusion Siqikang combined with Renshen Gejie powder can effectively improve the im-munity of patients and correct oxidation / antioxidant imbalance, greatly reduce the number of COPD exacerbations and duration, and even seizures can be controlled effectively and improve the quality of life of patients.