慢性丙型肝炎中医证型与HCV 1b亚型NS5A aa变异、IL28B SNP的关系

Relationship between TCM syndromes and amino acid mutation in NS5A aa,IL28B SNP of chronic HCV 1b infection

目的分析慢性丙型肝炎(CHC)中医证型与患者一般情况、肝功能、HCV RNA、NS5A aa变异及IL28B SNP的关系。方法通过回顾性研究,收集58例CHC患者的一般临床资料、血生化(ALT、AST、ALB、GLO、TBIL)、HCV RNA、NS5A aa变异及IL28B SNP,Spss 19.0软件分析各数据与中医证型的相关性。结果 58例CHC中医证型中,正虚邪恋型最多(43.1%),中医证型与年龄和球蛋白有关(P<0.05),肝郁脾虚型多见于年轻患者,瘀血阻络型和肝肾阴虚型多见于中老年患者。中医证型与HCV RNA、NS5A aa变异及IL28B SNP无统计学意义(P>0.05)。结论 CHC中医证型中,正虚邪恋型最多,中医证型与年龄和球蛋白有关,与HCV RNA、NS5A aa变异以及IL28B SNP无关。

Objective To analyze the relationship between traditional Chinese medicine（ TCM） syndromes and clinical data,liver function,HCV RNA,amino acid mutation in NS5 A and IL28 B SNP of chronic HCV 1b infection. Methods A total of 58 patients were analyzed retrospectively. To collect their clinical data,biochemistry（ ALT,AST,ALB,GLO,TBIL）,HCV RNA,mutation in NS5 A and IL28 B SNP. The correlations between TCM syndromes and data were analysised using the SPSS 19. 0 software. Results Among 58 patients enrolled in this study,the pattern of deficient vital QI leading to lingering of pathogen was maximum（ 43. 1%）. We identified that age and GLO were related to TCM syndromes（ P〈0. 05）,the majority patients of pattern of stagnation of liver-qi with deficiency of the spleen were younger,and the majority patients of obstruction of collaterals by blood stasis and yin deficiency of liver and kindey were older. There was no significant correlation was observed between the TCM syndromes and HCV RNA,amino acid mutation in NS5 A,IL28B SNP（ P〉0. 05）. Conclusion There may be some relationship between TCM symptoms and objective indexes in patients with CHC,TCM syndrome type have related with age and protein,but no related with HCV RNA NS5 A aa and IL28 B SNP.