振幅整合脑电图与新生儿缺氧缺血性脑病临床分度及头颅磁共振成像表现的相关性分析

The correlation analysis of amplitude-integrated and magnetic resonance imaging in infants with hypoxic-ischemic encephalopathy

目的探讨振幅整合脑电图（aEEG）与新生儿缺氧缺血性脑病（HIE）临床分度及头颅磁共振成像（MRI）表现的相关性，为早期判断HIE病情程度提供依据。方法入选90例足月HIE患儿，于生后12h内进行aEEG监测，生后3～7d行头颅MRI检查。根据aEEG监测结果将患儿分为aEEG正常、轻度异常、重度异常三组，与HIE患儿临床分度及头颅MRI分度进行Spearman相关分析。结果90例HIE患儿临床分度：轻度HIE 44例（48．9％），中度HIE29例（32．2％），重度HIE 17例（18．9％）。头颅MRI分度：轻度49例（54．4％），中度23例（25．6％），重度18例（20．0％）。aEEG监测结果：aEEG正常43例（47．8％），aEEG轻度异常25例（27．8％），aEEG重度异常22例（24．4％）。相关性分析结果显示，aEEG监测结果与HIE临床分度（r=0．9707，P〈0．01）和MRI分度（r=0．9335，P〈0．01）均呈正相关。结论aEEG严重程度与HIE临床分度及头颅MRI分度有相关性，可早期判断HIE病情程度。

Objective To investigate the correlation analysis of amplitude-integrated electro-encephalogram （aEEG） and magnetic resonance imaging （MRI） in infants with hypoxic-ischemic encephalopathy （HIE） to early evaluate the severity of HIE. Methods Ninety term infants with HIE were selected. They were detected by aEEG within 12 hours after birth, and accepted cranial MRI 3 to 7 days after birth. The infants were divided into 3 groups （aEEG normal, mild abnormality and severe abnormality） according to the result of aEEG. The Spearman correlation analysis was completed in infants with HIE between aEEG clinical grading and cranial MRI grading. Results In 90 infants with HIE, the clinical grading： mild HIE 44 cases （48.9%）, midrange HIE 29 cases （32.2%） and severe HIE 17 cases （18.9%）. Cranial MRI grading： mild 49 cases （54.4%）, midrange 23 cases （25.6%） and severe 18 cases （20.0%）. The result ofaEEG： aEEG normal 43 cases （47.8%）, aEEG mild abnormality 25 cases （27.8%） and aEEG sever abnormality 22 cases （24.4%）. The result of correlation analysis showed that aEEG grading was positive correlation with the HIE clinical grading （ r = 0.970 7, P 〈 0.01） and MRI grading （ r= 0.933 5, P 〈 0.01）. Conclusion The aEEG can early evaluate the severity of HIE.