外周血间充质干细胞在骨代谢中的应用研究进展

Research Progress of Application of Peripheral Blood Derived Mesenchymal Stem Cells in Bone Metabolism

外周血间充质干细胞是从外周血液中分离得到的一种成体干细胞,性质与骨髓间充质干细胞性质一致,异常分化引起骨代谢平衡改变导致骨量丢失。外周血间充质干细胞能即时动态地反映正在进行的骨重建状况,对代谢性骨病的早期诊断、预测骨丢失和监测药物疗效等均具有重要的临床意义,在骨代谢疾病的应用中前景广泛。但是,目前仍有许多关于间充质干细胞的疑问,包括其在骨重建、骨折愈合中的具体作用机制等还需进一步探究。

Peripheral blood mesenchymal stem cells（PBMSCs） is a kind of adult stem cells.Its charac-ter is similar to bone marrow mesenchymal stem cells ,and the change of bone metabolism caused by PBMSCs abnormal differentiation leads to bone loss .PBMSCs can reflect the status of bone remodeling timely ,dynami-cally,which has important clinical significance for early diagnosis of metabolic bone diseases,prediction of bone loss,monitoring drug efficacy,and has a wide prospect in the clinical application of bone metabolism diseases .But there are still many questions about mesenchymal stem cells ,which include the mechanisms in bone remodeling and fracture healing,therefore further research is still needed.