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HAND2甲基化在子宫内膜癌中的研究现状 被引量：1

Research Status of HAND2 Methylation in Endometrial Carcinoma
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摘要 随着当前人口老龄化和肥胖的流行,子宫内膜癌的发病率一直在上升。现代科学研究越来越多地关注表观遗传学异常与肿瘤发生、发展及其预后的关系,其中,DNA甲基化已成为肿瘤相关研究的热点之一。最新研究发现,心脏神经脊衍生物表达蛋白基因2(HAND2)甲基化是子宫内膜癌中一种常见的、重要的分子改变,其可能作为一项检测标志物用来早期发现肿瘤,甚至可以预测子宫内膜癌的风险,并对预防和治疗做出反应。 Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obe-sity epidemics.Modern scientific research has paid more and more attention to the relationship between epige-netic abnormalities and tumor occurrence,development and prognosis,of which,DNA methylation has become one of the hot topics in cancer research.Most recent studies have found that heart and neural crest deriva-tives-expressed transcript 2 methylation is a common and crucial molecular alteration in endometrial cancer that could potentially be employed as a biomarker for early detection of endometrial cancer and as a predictor of prevention and treatment response.
作者 石敏 尹香花
机构地区 扬州大学临床医学院妇产科
出处 《医学综述》 2015年第15期2744-2746,共3页 Medical Recapitulate
关键词 子宫内膜癌 心脏神经脊衍生物表达蛋白基因2 DNA甲基化 Endometrial carcinoma DNA methylation
分类号 R711.74 [医药卫生—妇产科学]
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参考文献27

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二级参考文献31

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医学综述
2015年 第15期

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