慢性阻塞性肺疾病合并贫血患者BODE变化

Study on the Changes of BODE Indexes in Patients with Chronic Obstructive Pulmonary Disease Complicated by Anemia

目的探讨慢性阻塞性肺疾病(COPD)急性加重期合并贫血患者的BODE指数变化。方法选择2010年5月至2013年1月江汉大学附属医院呼吸内科确诊的COPD急性加重期患者共273例。根据贫血标准分为两组,合并贫血的COPD患者(贫血组)40例,非贫血的COPD患者(非贫血组)随机选取40例。比较两组患者BODE指数,并对结果进行统计学分析。结果合并贫血的COPD患者发生率为14.6%,贫血组BODE指数高于非贫血组,差异有统计学意义(P<0.01)。其中体质指数、6 min步行试验距离、呼吸困难量表与非贫血组差异均有统计学意义(均P<0.01);两组患者肺功能指标(FEV1%,第1秒用力呼气容积占预计值百分比)比较差异无统计学意义(P>0.05)。结论贫血可恶化COPD运动耐量,影响患者生活质量,预后更差。

Objective To study the changes of BODE indexes in patients with chronic obstructive pul-monary disease（COPD） complicated by anemia. Methods A total of 273 patients diagnosed as acute exac-erbation of COPD in Department of Respiratory Medicine, the Affiliated Hospital of Jianghan University from May 2010 to Jan. 2013 were selected as research objects, according to the standard of anemia,the patients were divided into two groups, patients with anemia as anemia group （40 cases） and patients without anemic as non-anemia group（40 cases）. BODE indexes of the two groups were compared and statistically analyzed. Results Incidence of anemia in patients with COPD was 14.6%, BODE indexes of the anemia group were higher than non-anemic group, there were statistically significant differences （ P 〈 0.01 ）. Differences of BMI, 6MWD, and MMRC were statistically significant between the two groups （ P 〈 0. 01 ）, but difference of pulmo- nary function was not statistically significant between the two groups （ FEV1%, forced expiratory volume at the first second） （ P 〉 0. 05 ）. Conclusion Although the influence of anemia on pulmonary function in COPD patients has no statistically significant difference, anemia will worsen the COPD exercise tolerance, and impact on the quality of life in patients with poor prognosis.